Personalized Gut Microbiota Engineering for Enhanced Iron Absorption

A next-generation system for personalized gut microbiota engineering, enabling precision microbiome editing, and genetically engineered Lactiplantibacillus plantarum strains for optimized iron absorption and improved gut health.

The original patent, Lactiplantibacillus plantarum TCI837, methods for using the same, and iron supplement composition having the same, has limitations in terms of its broad applicability and individualized approach. The new inventive concept addresses these limitations by introducing a system that leverages machine learning algorithms, databases of microbiota profiles, and genetically engineered strains to provide a personalized solution for enhanced iron absorption and improved gut health.

The inventive concept comprises a database of microbiota profiles, a machine learning algorithm for predicting optimal Lactiplantibacillus plantarum strains for a given individual, and a composition comprising the predicted strain for promoting iron absorption and improving gut health. The system enables precision microbiome editing by identifying a subject's gut microbiota profile, selecting a customized Lactiplantibacillus plantarum strain based on the profile, and administering the strain to the subject. Additionally, the inventive concept includes genetically engineered Lactiplantibacillus plantarum strains that produce bioactive peptides enhancing iron absorption and improving gut health. The system can be integrated with devices for in-vitro gut microbiota simulation and computer-implemented methods for predicting the efficacy of Lactiplantibacillus plantarum strains.

The new claims introduce a paradigm shift in the field of gut microbiota engineering by incorporating machine learning algorithms, databases of microbiota profiles, and genetically engineered strains. These elements, in combination, provide a novel and non-obvious approach to personalized gut microbiota engineering, distinguishing the inventive concept from the original patent.

Alternative embodiments of the inventive concept could include the use of different machine learning algorithms, incorporation of additional data sources, such as genomic or proteomic data, and development of novel genetically engineered strains with enhanced iron absorption capabilities. Variations of the system could also include integration with wearable devices or mobile applications for real-time monitoring and personalized recommendations.

The inventive concept has significant commercial potential in the healthcare and nutrition industries, particularly in the areas of personalized medicine, gut health, and iron supplementation. The system could be marketed as a premium service for individuals seeking tailored solutions for improved gut health and iron absorption, with potential applications in the prevention and treatment of iron-deficiency anemia and other related disorders.