Enhanced Bioactive Extracts for Immune System Support

Publication ID: 24-11857587_0001_PTD
Published: October 28, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Enhanced Bioactive Extracts for Immune System Support,” Published Technical Disclosure No. 24-11857587_0001_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857587_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,587.

Summary of the Inventive Concept

The present inventive concept relates to the development of enhanced bioactive extracts from medicinal fungal species, optimized for immune system support through fermentation and combination with fruit extracts and prebiotic components.

Background and Problem Solved

The original patent disclosed a composition including fungal extract components from one or more medicinal fungal species, which had antiviral, antibacterial, antifungal, antiprotozoal, and immune boosting activities. However, the existing patent had limitations in terms of scalability, contamination risks, and limited customization options. The present inventive concept addresses these limitations by introducing a fermentation process, adding fruit extracts and prebiotic components, and designing a large-scale production system to minimize contamination and maximize yield.

Detailed Description of the Inventive Concept

The inventive concept comprises a system for enhancing immune system function, which includes a bioactive extract derived from a medicinal fungal species and a fruit extract. The bioactive extract is produced through a fermentation process using a nutrient-rich medium, and the fruit extract is added to the fermentation process to enhance the antiviral, antibacterial, antifungal, antiprotozoal, and immune boosting activities of the composition. The composition can be further customized for specific individuals or populations by analyzing their immune system profile and formulating the bioactive extract to address specific immune system deficiencies or imbalances. Additionally, the inventive concept includes a large-scale production system comprising a bioreactor for fermenting the mycelia of a medicinal fungal species and a downstream processing unit for purifying and concentrating the bioactive extract.

Novelty and Inventive Step

The new claims introduce several novel and non-obvious features compared to the original patent, including the use of fermentation, the addition of fruit extracts and prebiotic components, and the design of a large-scale production system. These features provide significant improvements in terms of scalability, contamination risks, and customization options, and are not obvious from the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different medicinal fungal species, varying the nutrient-rich medium and fermentation conditions, or incorporating additional components such as probiotics or vitamins. The inventive concept could also be adapted for use in different applications, such as animal health or agriculture.

Potential Commercial Applications and Market

The enhanced bioactive extracts have significant commercial potential in the health and wellness industry, particularly in the areas of immune system support and disease prevention. The large-scale production system and customization options could also make the inventive concept attractive to pharmaceutical and biotechnology companies.

CPC Classifications

SectionClassGroup
A A61 A61K36/074
A A61 A61K36/185
A A61 A61K2236/333

Field of Art

Biotechnology and pharmaceutical sciences, specifically focused on medicinal fungal extract production and immune system support compositions, with expertise in fermentation techniques, extract processing, and biological activity enhancement

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degree in biotechnology, microbiology, or pharmaceutical sciences, having practical experience in fungal extract production, fermentation processes, and biological activity screening, with knowledge of extraction techniques and immune system modulation

Obviousness Rationale

A person having ordinary skill in the art would recognize that the PTD's variations represent predictable extensions of the source patent's core teachings, involving standard biotechnological techniques like fermentation, extract combination, and process optimization that are well-established in the field of medicinal fungal extract production. The proposed modifications represent incremental improvements using known methodological approaches that would be obvious to a skilled practitioner seeking to enhance the original composition's effectiveness and production scalability.

Obvious Combinations & Variations

Source Patent Element
Bioactive extract from medicinal fungal species grown on cereal grains
PTD Variation
Introducing fermentation process with nutrient-rich medium for mycelia cultivation
Obviousness Reasoning
Fermentation is a standard technique in biotechnology for enhancing extract yield and biological activity, representing a known method for improving fungal extract production that would be obvious to implement
Source Patent Element
Composition with antiviral and immune boosting activities
PTD Variation
Adding fruit extract and prebiotic components to enhance immune system support
Obviousness Reasoning
Combining complementary biological extracts to improve functional properties is a predictable approach in nutraceutical and immunological formulation design
Source Patent Element
Extraction method using ethanol dilution
PTD Variation
Large-scale bioreactor system with downstream processing for extract purification
Obviousness Reasoning
Scaling up production using standard biotechnological engineering principles represents an obvious technological progression for commercial implementation
Source Patent Element
Medicinal fungal species selection from Ganoderma genus
PTD Variation
Customizing extract formulation based on individual immune system profile
Obviousness Reasoning
Personalized medicine approaches using targeted biological extract modification are well-established in biotechnological research and represent a predictable innovation
Source Patent Element
Composition with multiple biological activities
PTD Variation
Systematic approach to enhancing extract potency through fermentation and combination strategies
Obviousness Reasoning
Methodical optimization of biological extracts using known techniques represents an obvious approach to improving compositional effectiveness
35 U.S.C. § 103 Summary: Based on a comprehensive analysis of US Patent 11857587 and the presented Published Technical Disclosure, a person having ordinary skill in the art would find the claimed variations obvious and anticipated, as the proposed modifications represent predictable technological extensions employing standard biotechnological techniques for enhancing medicinal fungal extract production and biological activity, thereby rendering subsequent claims obvious under 35 U.S.C. Section 103 standards.

Original Patent Information

Patent NumberUS 11,857,587
TitleBioactive extract