Synergistic Bioactive Systems for Enhanced Immune Response and Health Monitoring

Publication ID: 24-11857587_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Bioactive Systems for Enhanced Immune Response and Health Monitoring,” Published Technical Disclosure No. 24-11857587_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857587_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,587.

Summary of the Inventive Concept

The present invention discloses novel synergistic combinations of bioactive extracts from medicinal fungal species with distinct technologies, including AI, IoT, blockchain, and new materials, to create powerful systems for immune system support, health monitoring, and antimicrobial resistance tracking.

Background and Problem Solved

The original patent relates to a composition including fungal extract components from one or more medicinal fungal species, providing antiviral, antibacterial, antifungal, antiprotozoal, and immune-boosting activities. However, there is a need for more advanced systems that integrate these bioactive extracts with other technologies to enhance their efficacy and provide real-time health monitoring and data analysis capabilities.

Detailed Description of the Inventive Concept

The new inventive concept comprises four distinct systems: 1) a bioactive extract-based system for monitoring and optimizing immune system responses, incorporating an AI-powered analytics module; 2) a personalized health monitoring method integrating a bioactive extract with a wearable IoT device and a blockchain-based data storage system; 3) a composition for immune system support featuring a synergistic combination of a bioactive extract, a native Australian bush food extract, and a graphene-based nanomaterial for enhanced bioavailability and targeted delivery; and 4) a system for antimicrobial resistance tracking, comprising a bioactive extract, a machine learning algorithm, and a cloud-based data repository.

Novelty and Inventive Step

The new claims introduce novel synergistic combinations of bioactive extracts with AI, IoT, blockchain, and new materials, providing enhanced functionality, real-time data analysis, and secure data management. These combinations are non-obvious and represent a significant advancement over the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include the use of different medicinal fungal species, varying ratios of bioactive extract to native Australian bush food extract, or the integration of additional technologies, such as robotics or 3D printing, to further enhance the systems' capabilities.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the healthcare and wellness industries, particularly in the areas of immune system support, health monitoring, and antimicrobial resistance tracking. Target markets may include pharmaceutical companies, healthcare providers, and wellness centers.

CPC Classifications

SectionClassGroup
A A61 A61K36/074
A A61 A61K36/185
A A61 A61K2236/333

Field of Art

Biotechnology and pharmaceutical sciences, specifically focused on medicinal fungal extracts, bioactive compound extraction, and health-related technological systems

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degrees in biotechnology, microbiology, or pharmaceutical sciences, possessing expertise in fungal extract preparation, biological compound characterization, and interdisciplinary technology integration

Obviousness Rationale

A PHOSITA would recognize that integrating bioactive fungal extracts with emerging technologies represents a predictable extension of existing biomedical research methodologies. The source patent's foundational work on medicinal fungal extracts provides a clear technological platform for exploring advanced applications and interdisciplinary combinations. The PTD's variations demonstrate logical technological progression by applying known extraction techniques to novel monitoring and delivery systems.

Obvious Combinations & Variations

Source Patent Element
Bioactive extract from medicinal fungal species (Ganoderma spp.) with immune system modulation properties
PTD Variation
Integration of fungal extract with AI-powered analytics for immune response tracking
Obviousness Reasoning
Combining biological extracts with computational analysis represents a predictable technological evolution, utilizing known machine learning techniques to enhance understanding of biological compounds' effects
Source Patent Element
Extraction method for fungal mycelia using ethanol concentration between 10-60%
PTD Variation
Incorporating graphene-based nanomaterials to enhance bioavailability and targeted delivery
Obviousness Reasoning
Nanomaterial enhancement of biological compounds is a known technique in drug delivery, representing an obvious optimization strategy for a PHOSITA seeking improved extract performance
Source Patent Element
Composition with antiviral, antibacterial, and immune-boosting activities
PTD Variation
Blockchain-based health data management system integrating bioactive extract monitoring
Obviousness Reasoning
Applying secure data management technologies to biological monitoring represents a straightforward technological extension using standard interdisciplinary integration techniques
Source Patent Element
Fungal extract production method using specific grain substrates
PTD Variation
Microfluidic bioreactor system with computer-aided design for optimizing extract production
Obviousness Reasoning
Advanced biomanufacturing techniques represent a predictable technological progression for improving extraction efficiency and compound yield
Source Patent Element
Medicinal fungal species extraction for health-related applications
PTD Variation
Integration with IoT wearable devices for real-time health monitoring
Obviousness Reasoning
Applying biological extracts to personalized health monitoring technologies represents an obvious combination of known techniques in biotechnology and digital health
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857587 and the disclosed technological variations, a person having ordinary skill in the art would find the claimed innovations obvious and lacking non-obvious inventive merit. The systematic integration of bioactive fungal extracts with computational, data management, and delivery technologies represents a predictable technological progression that would be readily conceived by a skilled practitioner in the field of biotechnology and pharmaceutical sciences.

Original Patent Information

Patent NumberUS 11,857,587
TitleBioactive extract