Enhanced Water-Soluble Cannabinoid and/or Terpene Extracts with Improved Bioavailability and Customizable Bulk Density

This inventive concept presents a system, method, and composition for creating and utilizing water-soluble, powdered cannabinoid and/or terpene extracts with improved bioavailability, customizable bulk density, and enhanced delivery options.

The original patent disclosed a water-soluble, powdered cannabinoid and/or terpene extract, but it had limitations in terms of bioavailability and bulk density control. The new inventive concept addresses these limitations by introducing a pH-dependent release mechanism, mucoadhesive excipients, and a solvent-emulsifier combination, enabling improved absorption and customizable dosage forms.

The inventive concept comprises a system for creating water-soluble, powdered cannabinoid and/or terpene extracts using a solvent-emulsifier combination, which enables improved solubility and bioavailability. The method involves incorporating the extract into a pharmaceutical composition with a pH-dependent release mechanism, triggered by changes in pH in the gastrointestinal tract. The composition may include mucoadhesive excipients to enhance residence time in the gastrointestinal tract. Additionally, the process for preparing the extract involves solubilizing, mixing with emulsifiers, and spray-drying to form a powder with customizable bulk density.

The new claims introduce a pH-dependent release mechanism, mucoadhesive excipients, and a solvent-emulsifier combination, which are not present in the original patent. These novel elements enable improved bioavailability, customizable bulk density, and enhanced delivery options, thereby providing a non-obvious advancement over the prior art.

Alternative embodiments may include using different solvents, emulsifiers, or mucoadhesive excipients. Variations of the pharmaceutical composition may involve different pH-dependent release mechanisms or additional excipients to enhance bioavailability. The inventive concept could also be applied to other bioactive compounds beyond cannabinoids and terpenes.

The inventive concept has significant commercial potential in the pharmaceutical and nutraceutical industries, particularly in the development of cannabis-based products with improved bioavailability and customizable dosage forms. Target markets may include companies focused on cannabis-based therapeutics, nutraceuticals, and wellness products.