Enhanced Composition and System for Protecting Liver, Intestines, and Enhancing Immunity in Freshwater Fish

Publication ID: 24-11857591_0001_PTD
Published: October 28, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Enhanced Composition and System for Protecting Liver, Intestines, and Enhancing Immunity in Freshwater Fish,” Published Technical Disclosure No. 24-11857591_0001_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857591_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,591.

Summary of the Inventive Concept

The present inventive concept relates to a novel composition and system for protecting liver, intestines, and enhancing immunity in freshwater fish, addressing the limitations of existing solutions by improving bioavailability, targeted delivery, and real-time monitoring.

Background and Problem Solved

The original patent disclosed a composition for protecting liver, protecting intestines, and enhancing immunity for freshwater fish, but it had limitations in terms of bioavailability, particle size distribution, and monitoring health status. The present inventive concept addresses these limitations by introducing a novel excipient, modified particle size distribution, synergistic blend of antioxidants, and real-time monitoring system.

Detailed Description of the Inventive Concept

The novel composition comprises a synergistic blend of herbal ingredients with improved bioavailability due to the addition of a novel excipient, allowing for increased absorption rates in the fish's digestive system. The composition is formulated with a modified particle size distribution to enhance targeted delivery to the liver and intestines. Furthermore, the composition includes a synergistic blend of antioxidants to reduce oxidative stress in the fish's body. The system for monitoring the health status of freshwater fish comprises a sensor for detecting biomarkers indicative of liver and intestinal health, and a data analytics module for providing real-time feedback to fish farmers. The novel drying process preserves the bioactive compounds of the herbal ingredients.

Novelty and Inventive Step

The present inventive concept introduces several novel features, including the use of a novel excipient, modified particle size distribution, synergistic blend of antioxidants, and real-time monitoring system, which provide significant improvements over the existing solutions. The combination of these features constitutes an inventive step, as it provides a new and non-obvious solution to the problems addressed.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include different formulations of the composition, such as varying the ratio of herbal ingredients or adding other nutrients. The system for monitoring the health status of freshwater fish may be adapted for use in different aquaculture settings, such as saltwater fish farming or shrimp farming. The novel drying process may be applied to other herbal ingredients or compositions.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in the aquaculture industry, particularly in freshwater fish farming. The improved composition and system can provide a competitive advantage to fish farmers, enabling them to reduce mortality rates, improve fish health, and increase productivity. The market for aquaculture technology is growing rapidly, driven by increasing demand for sustainable and efficient food production.

CPC Classifications

SectionClassGroup
A A61 A61K36/19
A A23 A23K10/30
A A23 A23K50/80
A A61 A61K31/145
A A61 A61K33/00
A A61 A61K36/22
A A61 A61K36/315
A A61 A61K36/704
A A61 A61K36/708
A A61 A61P37/04

Field of Art

Aquaculture biotechnology, specifically herbal compositions for fish health management, involving pharmaceutical formulation, nutritional supplementation, and veterinary medicine for aquatic species

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degree in aquaculture, veterinary science, or pharmaceutical biotechnology, possessing expertise in herbal medicine preparation, understanding of fish physiological systems, and knowledge of nutraceutical formulation techniques

Obviousness Rationale

A PHOSITA would recognize that the PTD's variations represent predictable extensions of the source patent's core composition, applying standard pharmaceutical development techniques to enhance bioavailability, delivery, and monitoring of herbal fish health treatments. The modifications represent incremental improvements using known methodological approaches in nutraceutical design. The synergistic combinations and monitoring system would be considered logical progressions of existing aquaculture health management strategies.

Obvious Combinations & Variations

Source Patent Element
Herbal composition with specific ingredient ratios for fish health
PTD Variation
Addition of novel excipient to increase absorption rates
Obviousness Reasoning
Enhancing bioavailability through excipient selection is a standard pharmaceutical formulation technique, representing a predictable optimization of existing herbal composition
Source Patent Element
Raw material processing method involving crushing and sieving
PTD Variation
Novel drying process to preserve bioactive compounds
Obviousness Reasoning
Preservation techniques for herbal ingredients are well-known in the art, representing an obvious refinement of existing processing methodologies
Source Patent Element
Composition targeting liver and intestinal health in freshwater fish
PTD Variation
Incorporating synergistic antioxidant blend to reduce oxidative stress
Obviousness Reasoning
Antioxidant supplementation is a recognized strategy in nutraceutical development, representing a logical extension of existing health-protective formulations
Source Patent Element
Herbal composition for fish immunity enhancement
PTD Variation
Real-time health monitoring system with biomarker detection
Obviousness Reasoning
Integration of diagnostic monitoring with nutritional interventions is a predictable advancement in precision aquaculture management
Source Patent Element
Fixed herbal ingredient ratios for fish health composition
PTD Variation
Modified particle size distribution for targeted delivery
Obviousness Reasoning
Particle engineering to improve targeted delivery is a standard pharmaceutical technique, representing an obvious optimization of existing compositional approaches
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857591 and the published technical disclosure, a person having ordinary skill in the art would find the claimed variations obvious, as they represent predictable extensions of known aquaculture health management techniques, utilizing standard pharmaceutical formulation methodologies to incrementally improve herbal composition design, bioavailability, and diagnostic monitoring strategies.

Original Patent Information

Patent NumberUS 11,857,591
TitleComposition for protecting liver, protecting intestines and enhancing immunity for freshwater fish, and preparation and application thereof