Personalized Neuro-Adaptive Treatment System for ADHD

Publication ID: 24-11857592_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Personalized Neuro-Adaptive Treatment System for ADHD,” Published Technical Disclosure No. 24-11857592_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857592_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,592.

Summary of the Inventive Concept

A wearable, AI-driven system for treating attention-deficit hyperactivity disorder (ADHD) by adapting to individual brain activity, genomic data, and behavioral patterns, providing a personalized and optimized treatment plan.

Background and Problem Solved

The original patent disclosed a method for treating ADHD using a Radix Polygalae extract. However, this approach has limitations, such as a one-size-fits-all approach, lack of real-time monitoring, and limited understanding of individual variability. The new inventive concept addresses these limitations by integrating wearable technology, machine learning, and genomic analysis to provide a more effective and personalized treatment.

Detailed Description of the Inventive Concept

The system comprises a wearable device that administers a composition comprising a Radix Polygalae extract, which is configured to monitor and adapt to the subject's brain activity and cognitive performance in real-time. The system utilizes machine learning algorithms to analyze genomic data, brain activity, and behavioral patterns, generating a customized treatment plan. The treatment plan may include a personalized composition comprising a Radix Polygalae extract, which is delivered through a transcranial magnetic stimulation (TMS) device. The system also enables remote monitoring and treatment, allowing for real-time adjustments and optimization.

Novelty and Inventive Step

The new inventive concept introduces a paradigm shift in ADHD treatment by integrating wearable technology, machine learning, and genomic analysis to provide a personalized and optimized treatment plan. This approach is novel and non-obvious compared to the original patent, which relied on a fixed composition and administration method.

Alternative Embodiments and Variations

Alternative embodiments may include using different types of wearable devices, such as implantable devices or mobile applications, or incorporating additional data sources, such as environmental or social factors. Variations may also include using different machine learning algorithms or incorporating additional therapeutic modalities, such as cognitive training or behavioral therapy.

Potential Commercial Applications and Market

The personalized neuro-adaptive treatment system has significant commercial potential in the ADHD treatment market, which is projected to reach $25 billion by 2025. The system's ability to provide personalized and optimized treatment plans, combined with its remote monitoring and treatment capabilities, makes it an attractive solution for patients, clinicians, and payers.

CPC Classifications

SectionClassGroup
A A61 A61K36/69
A A61 A61K9/0053
A A61 A61K9/485
A A61 A61K9/4825
A A61 A61K9/4858
A A61 A61K47/02
A A61 A61K47/12
A A61 A61P25/28
A A61 A61K2236/333

Original Patent Information

Patent NumberUS 11,857,592
TitlePolygala extract for the treatment of attention-deficit hyperactivity disorder
Assignee(s)BioLite Inc.