Curcumin-based Neurokinin 3 Receptor Modulation for Animal Health

This inventive concept leverages the core technology of curcumin compositions as neurokinin 3 (NK3) antagonists to develop novel applications in animal health, addressing unmet needs in companion animals, agricultural livestock, aquaculture, and poultry.

The original patent disclosed curcumin compositions as NK3 antagonists for human therapeutic applications. However, the limitations of this technology were restricted to human use cases, leaving a significant gap in addressing similar health issues in animals. This inventive concept solves this problem by exploring new applications and use cases for curcumin-based NK3 receptor modulation in animal health.

The inventive concept involves the development of curcumin compositions specifically formulated to cross the blood-brain barrier and inhibit NK3 receptor activity in various animal species. This is achieved through the creation of novel formulations, such as veterinary formulations, feed supplements, and aquaculture compositions, which selectively target NK3 receptors in the central nervous system of animals. The new claims encompass a range of applications, including treating neurodegenerative disorders in companion animals, reducing anxiety in agricultural livestock, and improving growth rates in poultry.

The new claims introduce a novel and non-obvious application of curcumin-based NK3 receptor modulation in animal health, distinct from the original patent's focus on human therapeutic applications. The inventive concept's novelty lies in its tailored formulations and targeted delivery mechanisms, which enable effective modulation of NK3 receptors in various animal species.

Alternative embodiments of the inventive concept could include the development of transdermal patches, injectable formulations, or oral tablets for animal use. Variations could also involve combining curcumin with other natural compounds or pharmacological agents to enhance its efficacy and bioavailability.

The inventive concept has significant commercial potential in the animal health industry, with potential applications in veterinary medicine, agricultural production, and aquaculture. The target market includes animal health companies, veterinarians, farmers, and aquaculture operators seeking innovative solutions to improve animal welfare and productivity.