Synergistic Combinations for Neurokinin-3 Receptor-Related Disorders

Publication ID: 24-11857594_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Combinations for Neurokinin-3 Receptor-Related Disorders,” Published Technical Disclosure No. 24-11857594_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857594_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,594.

Summary of the Inventive Concept

A novel system integrating curcumin compositions with AI, IoT, blockchain, and other technologies to treat neurokinin-3 receptor-related disorders, offering personalized and optimized treatment outcomes.

Background and Problem Solved

The original patent identified curcumin compositions as potent NK3 antagonists, but it lacked integration with other technologies to enhance treatment efficacy and patient outcomes. This inventive concept addresses this limitation by combining curcumin compositions with AI, IoT, blockchain, and other technologies to create a more powerful system for treating neurokinin-3 receptor-related disorders.

Detailed Description of the Inventive Concept

The inventive concept comprises a curcumin composition, which may be combined with other natural ingredients, such as green tea extract and phycocyanin, in synergistic ratios. This composition is integrated with AI-powered diagnostic tools to identify patients with high neurokinin-3 receptor expression, blockchain-based platforms for secure data storage and tracking, and IoT sensors for real-time monitoring of neurokinin-3 receptor activity. Additionally, genomic sequencing and machine learning algorithms are used to personalize treatment and optimize curcumin composition formulations. The system provides a controlled release profile of the composition through nanoparticle encapsulation, ensuring targeted and efficient treatment.

Novelty and Inventive Step

The new claims introduce a synergistic combination of curcumin compositions with AI, IoT, blockchain, and other technologies, which is not obvious from the original patent. The integration of these distinct technologies creates a novel system that provides personalized and optimized treatment outcomes for neurokinin-3 receptor-related disorders.

Alternative Embodiments and Variations

Alternative embodiments may include varying the ratio of curcumin composition to other natural ingredients, using different AI algorithms for diagnostic and predictive purposes, or incorporating other technologies such as nanotechnology or 3D printing to enhance treatment efficacy. Variations may also include using the system for treating other diseases or disorders related to neurokinin-3 receptor expression.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the pharmaceutical and healthcare industries, particularly in the areas of personalized medicine, AI-assisted diagnostics, and IoT-enabled healthcare. The target market includes patients with neurokinin-3 receptor-related disorders, such as anxiety, depression, and chronic pain, as well as healthcare providers and pharmaceutical companies seeking to develop more effective treatment options.

CPC Classifications

SectionClassGroup
A A61 A61K36/9066
A A61 A61K31/26
A A61 A61K36/82
A A61 A61P15/12

Original Patent Information

Patent NumberUS 11,857,594
TitleCurcumin compositions and methods of use as an NK3 antagonist
Assignee(s)JDS Therapeutics, LLC