Published Technical Disclosure Archive

Bacteriocin-based compositions for human health and performance

Publication ID: 24-11857596_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Bacteriocin-based compositions for human health and performance,” Published Technical Disclosure No. 24-11857596_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857596_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,596.

Summary of the Inventive Concept

The inventive concept relates to the application of bacteriocin-based compositions to improve human health and performance, specifically in the areas of cognitive function, neurodegenerative diseases, athletic performance, mental health disorders, and sleep quality.

Background and Problem Solved

The original patent disclosed a coated-type feed additive composition for improving body weight gain of livestock or feed conversion ratio for livestock. However, the increasing demand for innovative solutions in human health and performance necessitates the exploration of new applications for bacteriocin-based compositions. The inventive concept addresses the problem of limited understanding of bacteriocin-based compositions' potential in human health and performance.

Detailed Description of the Inventive Concept

The inventive concept involves the use of bacteriocin-based compositions to strengthen the blood-brain barrier, reduce the risk of neurodegenerative diseases, enhance athletic performance, treat mental health disorders, and improve sleep quality. The compositions may be administered as supplements or incorporated into food products. The bacteriocins, such as nisin, subtilin, plantaricin, and gasseri, are selected for their ability to strengthen the gut-blood barrier, reduce inflammation, and promote a healthy gut microbiome.

Novelty and Inventive Step

The new claims introduce a novel application of bacteriocin-based compositions in human health and performance, which is distinct from the original patent's focus on livestock feed. The inventive step lies in the recognition of the potential of bacteriocin-based compositions to address specific human health and performance challenges, and the development of compositions and methods tailored to these applications.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include the use of different bacteriocins, varying dosages, or different administration routes. Variations may also include the combination of bacteriocin-based compositions with other nutrients or bioactive compounds to enhance their effects.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the human health and performance markets, including the sports nutrition, mental health, and sleep quality industries. The market demand for innovative solutions in these areas is high, and the bacteriocin-based compositions offer a unique value proposition.

CPC Classifications

SectionClassGroup
A A61 A61K38/12
A A23 A23K10/16
A A23 A23K20/111
A A23 A23K20/142
A A23 A23K20/195
A A23 A23K20/26
A A23 A23K40/30
A A23 A23K50/75
A A61 A61K31/198
A A61 A61K31/405
A A61 A61K31/683
A A61 A61K35/747
A A61 A61K47/22
A A61 A61K47/44
A A23 A23V2400/157
A A23 A23V2400/169

Field of Art

Biotechnology and nutritional science, specifically focused on bacteriocin-based compositions for biological enhancement, with expertise in microbial metabolites, nutritional supplements, and biological barrier interactions

Person of Ordinary Skill (PHOSITA) Profile

A researcher or practitioner with advanced degrees in microbiology, biochemistry, or nutritional sciences, possessing knowledge of bacteriocin properties, microbiome interactions, and cross-species biological applications

Obviousness Rationale

A PHOSITA would recognize the inherent transferability of bacteriocin properties between livestock and human biological systems, understanding that the core mechanism of strengthening cellular membranes and modulating microbiome interactions is fundamentally similar across mammalian species. The source patent's demonstration of bacteriocins improving livestock performance provides a clear scientific foundation for exploring similar physiological benefits in human health applications. The technical principles of bacteriocin functionality are sufficiently established that extending their application from animal feed to human performance represents a predictable variation within the field.

Obvious Combinations & Variations

Source Patent Element
Bacteriocin composition for improving livestock body weight gain and feed conversion ratio
PTD Variation
Applying bacteriocin compositions to improve human cognitive function and neurological health
Obviousness Reasoning
Known bacteriocin mechanisms of cellular membrane strengthening are directly translatable between biological systems, representing a predictable extension of existing scientific understanding
Source Patent Element
Use of specific bacteriocins like nisin, subtilin, plantaricin, and gasseri in feed additives
PTD Variation
Incorporating identical bacteriocins into human nutritional supplements targeting gut-brain axis
Obviousness Reasoning
Identical molecular compounds with demonstrated biological activity can be expected to produce similar beneficial effects when applied to different physiological contexts
Source Patent Element
Microorganism sources like Bacillus subtilis and Lactobacillus plantarum for producing bacteriocins
PTD Variation
Utilizing same microbial sources for generating bacteriocin compositions targeting human health interventions
Obviousness Reasoning
Established microbial production methods are directly transferable across biological research domains, representing a known and predictable technological approach
Source Patent Element
Coated-type feed additive composition with core containing physiologically active substances
PTD Variation
Developing bacteriocin-based supplements with targeted delivery mechanisms for human health applications
Obviousness Reasoning
Encapsulation and targeted delivery techniques are well-understood engineering approaches that a skilled practitioner would readily adapt across different biological contexts
35 U.S.C. § 103 Summary: Based on US Patent 11857596's comprehensive disclosure of bacteriocin compositions and their physiological mechanisms, the present publication demonstrates that extending such compositions to human health applications represents an obvious variation to a Person Having Ordinary Skill In The Art. The technical principles, specific bacteriocin compounds, and microbiological production methods disclosed in the source patent provide sufficient foundational knowledge to render the human health applications predictable and non-inventive under standard obviousness analysis.

Original Patent Information

Patent NumberUS 11,857,596
TitleAnimal feed additive and animal feed
Assignee(s)AJINOMOTO CO., INC.