Synergistic Gene Delivery Platforms

Publication ID: 24-11857598_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Gene Delivery Platforms,” Published Technical Disclosure No. 24-11857598_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857598_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,598.

Summary of the Inventive Concept

Integrating self-replicating cell selective gene delivery compositions with AI, IoT, blockchain, and novel materials to create powerful, personalized gene therapy systems

Background and Problem Solved

Despite advances in gene therapy, existing approaches often lack precision, efficiency, and scalability. The original patent's self-replicating cell selective gene delivery compositions addressed some of these limitations, but further integration with distinct technologies is needed to unlock full potential. The new inventive concept bridges this gap by combining the original patent's technology with AI, IoT, blockchain, and novel materials to create a more effective and personalized gene delivery system

Detailed Description of the Inventive Concept

The new inventive concept integrates the original patent's self-replicating cell selective gene delivery compositions with AI modules for optimizing gene expression, IoT-enabled sensors for real-time monitoring, blockchain-based health record systems for secure data storage and sharing, and nanoparticle-based delivery systems incorporating novel materials for enhanced biocompatibility and targeted cellular uptake. These synergistic combinations enable personalized gene therapy, improved gene editing efficacy, and decentralized gene regulation. The AI module analyzes real-time cellular response data to optimize gene expression, while the IoT-enabled sensors provide continuous monitoring of gene expression and editing efficacy. The blockchain-based health record system ensures secure storage and sharing of gene expression data, and the nanoparticle-based delivery system enhances targeted cellular uptake and biocompatibility

Novelty and Inventive Step

The new claims introduce novel synergistic combinations of the original patent's technology with AI, IoT, blockchain, and novel materials, providing a more effective, personalized, and secure gene delivery system. The inventive step lies in the unexpected integration of these distinct technologies to create a more powerful and efficient gene therapy platform

Alternative Embodiments and Variations

Alternative embodiments may include integrating the gene delivery composition with other AI algorithms, such as machine learning or deep learning, or using different types of IoT-enabled sensors or blockchain-based systems. Variations may include using different novel materials for the nanoparticle-based delivery system or incorporating additional technologies, such as CRISPR-Cas9 gene editing, to further enhance the gene therapy platform

Potential Commercial Applications and Market

The new inventive concept has significant commercial potential in the gene therapy market, particularly in the areas of personalized medicine, gene editing, and decentralized health data management. Target industries include biotechnology, pharmaceuticals, and healthcare, with potential applications in cancer treatment, rare genetic disorders, and regenerative medicine

CPC Classifications

SectionClassGroup
A A61 A61K38/1709
A A61 A61K31/7088
A A61 A61K31/7115
C C12 C12Y207/07048
C C12 C12N2310/113
C C12 C12N2710/10343

Original Patent Information

Patent NumberUS 11,857,598
TitleSelf-replicating cell selective gene delivery compositions, methods, and uses thereof
Assignee(s)University of South Florida