Intelligent Gene Delivery Systems

Publication ID: 24-11857598_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Intelligent Gene Delivery Systems,” Published Technical Disclosure No. 24-11857598_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857598_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,598.

Summary of the Inventive Concept

This inventive concept integrates self-replicating cell selective gene delivery compositions with advanced technologies like AI, IoT, blockchain, and machine learning to create a more powerful and efficient gene delivery system.

Background and Problem Solved

Despite the progress in gene therapy, targeted gene delivery remains a significant challenge. The original patent's self-replicating cell selective gene delivery compositions have limitations in terms of tracking, optimization, and personalization. This new inventive concept addresses these limitations by combining the patented technology with synergistic technologies to create a more effective and efficient gene delivery system.

Detailed Description of the Inventive Concept

The new system comprises a self-replicating cell selective gene delivery composition, a blockchain-based tracking module, and a machine learning algorithm for optimizing gene delivery routes. The blockchain module enables secure, transparent, and tamper-proof tracking of gene expression and patient data, while the machine learning algorithm identifies the most effective gene delivery routes. Additionally, the system can be integrated with IoT-enabled bioreactors for customized composition generation and AI-powered genomic analysis for personalized gene therapy.

Novelty and Inventive Step

The new claims introduce the synergistic combination of self-replicating cell selective gene delivery compositions with advanced technologies like AI, IoT, blockchain, and machine learning, which is not obvious from the original patent. The integration of these technologies enables a more efficient, personalized, and secure gene delivery system.

Alternative Embodiments and Variations

Alternative embodiments may include using different types of blockchain networks, incorporating additional AI algorithms for gene expression prediction, or integrating with other IoT devices for real-time monitoring. Variations may also include using different types of gene delivery compositions or targeting different cell types.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential in the gene therapy market, particularly in personalized medicine and targeted gene delivery. The system's ability to optimize gene delivery routes, track gene expression, and enable secure data management makes it an attractive solution for pharmaceutical companies, biotech firms, and research institutions.

CPC Classifications

SectionClassGroup
A A61 A61K38/1709
A A61 A61K31/7088
A A61 A61K31/7115
C C12 C12Y207/07048
C C12 C12N2310/113
C C12 C12N2710/10343

Original Patent Information

Patent NumberUS 11,857,598
TitleSelf-replicating cell selective gene delivery compositions, methods, and uses thereof
Assignee(s)University of South Florida