GPCR Heteromer-based Solutions for Diverse Industries

Publication ID: 24-11857600_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “GPCR Heteromer-based Solutions for Diverse Industries,” Published Technical Disclosure No. 24-11857600_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857600_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,600.

Summary of the Inventive Concept

The inventive concept leverages the core technology of GPCR heteromer inhibitors to develop innovative solutions for various industries, including agriculture, industrial fermentation, water quality monitoring, environmental pollution mitigation, and animal health.

Background and Problem Solved

The original patent disclosed inhibitors of novel, functional GPCR heteromers, particularly CXCR4-HRH1 heteromers, for cancer treatment. However, the potential applications of GPCR heteromers extend beyond oncology. The inventive concept addresses the limitation of the original patent by exploring new use cases that capitalize on the versatility of GPCR heteromers.

Detailed Description of the Inventive Concept

The inventive concept encompasses a range of systems, methods, and devices that utilize GPCR heteromers to tackle distinct challenges in various industries. For instance, in agriculture, GPCR heteromer-based sensors can monitor and predict crop yields by detecting and quantifying GPCR heteromers in plant cells. In industrial fermentation, identifying and inhibiting specific GPCR heteromers can optimize fermentation efficiency. Similarly, GPCR heteromer-based biosensors can detect and diagnose waterborne pathogens, while a network of GPCR heteromer-based sensors can predict and mitigate environmental pollution. In animal health, GPCR heteromer inhibitors can improve growth and development in livestock.

Novelty and Inventive Step

The new claims introduce novel applications and use cases for GPCR heteromers, which are not obvious from the original patent. The inventive step lies in recognizing the potential of GPCR heteromers to solve diverse industry-specific problems and developing innovative solutions that capitalize on this potential.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include the use of different GPCR heteromers, varying sensor configurations, or alternative data analysis approaches. Additionally, the inventive concept could be adapted for use in other industries, such as biomedical diagnostics or pharmaceutical development.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential across multiple industries, including agriculture, industrial fermentation, water quality monitoring, environmental pollution mitigation, and animal health. The target market includes companies, research institutions, and government agencies operating in these industries, as well as potential partnerships with biotechnology and pharmaceutical companies.

CPC Classifications

SectionClassGroup
A A61 A61K38/195
A A61 A61K31/138
A A61 A61K31/395
A A61 A61K31/403
A A61 A61K31/451
A A61 A61K31/4545
A A61 A61K31/47
A A61 A61K31/495
A A61 A61K31/5415
A A61 A61K38/12
A A61 A61K39/3955
A A61 A61P35/00
C C07 C07K16/286
C C07 C07K16/2866
A A61 A61K2039/505
A A61 A61K2039/507
C C07 C07K2317/21
C C07 C07K2317/76

Field of Art

Molecular and Cellular Pharmacology, with expertise in G-Protein Coupled Receptor (GPCR) heteromer interactions, signal transduction, and biotechnological applications across pharmaceutical, agricultural, and environmental domains

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degree (PhD) in molecular biology or pharmacology, experienced in GPCR signaling mechanisms, sensor design, interdisciplinary biotechnology applications, and understanding of heteromer interaction dynamics

Obviousness Rationale

A PHOSITA would recognize that the fundamental principles of GPCR heteromer interactions disclosed in US 11857600 provide a versatile technological platform that can be systematically adapted across multiple industrial domains. The source patent's detailed characterization of CXCR4-HRH1 heteromer signaling mechanisms inherently suggests broader applicability beyond cancer treatment. By understanding the core signal transduction principles, a skilled practitioner would naturally explore translational applications in sensing, monitoring, and intervention strategies across different biological systems.

Obvious Combinations & Variations

Source Patent Element
CXCR4-HRH1 heteromer components that colocalize and physically interact via direct or intermediate protein interactions
PTD Variation
Using GPCR heteromer interaction principles to develop agricultural crop yield monitoring sensors
Obviousness Reasoning
A PHOSITA would recognize that the fundamental protein interaction mechanisms are transferable across biological systems, making sensor design a predictable engineering extension of the original heteromer characterization
Source Patent Element
Enhanced downstream signaling mechanisms involving calcium mobilization in heteromeric receptor complexes
PTD Variation
Developing GPCR heteromer-based biosensors for pathogen detection in water samples
Obviousness Reasoning
Signal transduction principles are consistent across biological contexts, allowing a skilled practitioner to adapt the sensing mechanism as a known technique for detecting molecular interactions
Source Patent Element
Method of inhibiting cellular signaling through targeted heteromer component inhibition
PTD Variation
Optimizing industrial fermentation processes by introducing GPCR heteromer inhibitors
Obviousness Reasoning
Inhibition strategies represent a predictable and systematic approach to modulating cellular processes, which a PHOSITA would recognize as a straightforward technical adaptation
Source Patent Element
Quantitative assessment of heteromer interactions and downstream signaling effects
PTD Variation
Environmental pollution monitoring using networked GPCR heteromer-based sensors
Obviousness Reasoning
Extending sensor and quantification technologies across different environmental matrices represents a logical and predictable technological progression for a skilled practitioner
Source Patent Element
Characterization of heteromer interactions in cellular signaling contexts
PTD Variation
Developing animal health interventions targeting specific GPCR heteromer interactions
Obviousness Reasoning
Translating molecular interaction principles into targeted biological interventions is a standard approach in biotechnological research, representing an obvious extension of known techniques
35 U.S.C. § 103 Summary: Based on the comprehensive disclosure of GPCR heteromer interaction principles in US 11857600, a Person Having Ordinary Skill In The Art would find the variations disclosed herein to be obvious extensions of the foundational technological teachings. The systematic application of heteromer interaction mechanisms across diverse industrial domains represents a predictable and logical technological progression that does not rise to the level of non-obvious innovation, thereby rendering potential claims in this domain anticipated and obvious in light of the prior art.

Original Patent Information

Patent NumberUS 11,857,600
TitleGPCR heteromer inhibitors and uses thereof
Assignee(s)GPCR THERAPEUTICS, INC.