Personalized Cancer Treatment System with Targeted Fusion Protein and Anticancer Agent

Publication ID: 24-11857601_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Personalized Cancer Treatment System with Targeted Fusion Protein and Anticancer Agent,” Published Technical Disclosure No. 24-11857601_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857601_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,601.

Summary of the Inventive Concept

A next-generation cancer treatment system that combines a genetically engineered fusion protein dimer with a tailored anticancer agent, providing a personalized and targeted approach to cancer therapy.

Background and Problem Solved

The original patent disclosed a pharmaceutical composition for cancer treatment comprising a fusion protein dimer and an anticancer agent. However, this composition has limitations in terms of its generic approach to cancer treatment, lacking the ability to target specific cancer cells based on their genetic profile. The new inventive concept addresses this limitation by engineering the fusion protein dimer to target specific cancer cells and tailoring the anticancer agent to the specific genetic profile of the cancer cells.

Detailed Description of the Inventive Concept

The new inventive concept consists of a system for personalized cancer treatment, comprising a fusion protein dimer engineered to target specific cancer cells based on their genetic profile, and an anticancer agent tailored to the specific genetic profile of the cancer cells. The fusion protein dimer is designed to bind specifically to cancer cells with a particular genetic mutation, allowing for targeted delivery of the anticancer agent. The anticancer agent is selected based on the genetic profile of the cancer cells, ensuring maximum efficacy and minimal side effects. The system also includes a method for real-time monitoring of cancer treatment, allowing for adjustments to the dosage of the anticancer agent as needed.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious compared to the original patent, as it introduces a personalized and targeted approach to cancer treatment, using genetically engineered fusion protein dimers and tailored anticancer agents. The inventive step lies in the engineering of the fusion protein dimer to target specific cancer cells and the tailoring of the anticancer agent to the specific genetic profile of the cancer cells.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different types of fusion protein dimers, such as those engineered to target specific cancer stem cells or those conjugated to nanoparticles for targeted delivery. Variations could also include the use of different types of anticancer agents, such as immunotherapies or gene therapies.

Potential Commercial Applications and Market

The new inventive concept has significant commercial potential in the field of cancer treatment, with a target market including pharmaceutical companies, hospitals, and research institutions. The system's ability to provide personalized and targeted cancer treatment could revolutionize the field of oncology, offering a more effective and efficient approach to cancer therapy.

CPC Classifications

SectionClassGroup
A A61 A61K38/2013
A A61 A61K31/337
A A61 A61K31/444
A A61 A61K31/4439
A A61 A61K31/47
A A61 A61K31/4709
A A61 A61K31/502
A A61 A61K31/506
A A61 A61K31/5025
A A61 A61K31/519
A A61 A61K31/708
A A61 A61K33/243
A A61 A61K38/1774
A A61 A61K39/3955
A A61 A61K45/06
A A61 A61P35/00

Field of Art

Biotechnology and pharmaceutical research, specifically targeted cancer therapeutics involving protein engineering, immunotherapy, and personalized medicine approaches

Person of Ordinary Skill (PHOSITA) Profile

A researcher with a PhD in biotechnology or molecular biology, expertise in protein engineering, cancer therapeutics, immunology, with knowledge of fusion protein design, targeted drug delivery, and cancer treatment strategies

Obviousness Rationale

A person having ordinary skill would recognize that personalizing the fusion protein dimer and tailoring anticancer agents based on genetic profiles represents a predictable extension of the source patent's core technology of combining CD80 protein, IL-2 protein, and anticancer agents. The PTD's variations apply standard biotechnological techniques of targeted drug delivery and personalized medicine to the existing fusion protein framework. These modifications would be considered routine optimization within the skill of an ordinary practitioner in cancer therapeutic research.

Obvious Combinations & Variations

Source Patent Element
Fusion protein dimer comprising CD80 fragment and IL-2 variant
PTD Variation
Engineering fusion protein dimer to target specific cancer cells based on genetic profile
Obviousness Reasoning
Targeting specific cell populations is a known technique in protein engineering, representing a predictable application of existing protein design principles
Source Patent Element
Pharmaceutical composition with anticancer agents
PTD Variation
Tailoring anticancer agent selection based on specific genetic cancer cell profiles
Obviousness Reasoning
Personalized medicine approach of matching therapeutic agents to genetic characteristics is a well-established strategy in oncology research
Source Patent Element
Fusion protein with CD80 and IL-2 components
PTD Variation
Conjugating fusion protein dimer to nanoparticles for targeted delivery
Obviousness Reasoning
Nanoparticle-based drug delivery is a known technique for improving targeting and reducing systemic toxicity, representing a predictable technological improvement
Source Patent Element
Cancer treatment pharmaceutical composition
PTD Variation
Real-time monitoring system for tracking treatment efficacy and adjusting dosage
Obviousness Reasoning
Adaptive treatment monitoring is a standard approach in precision medicine, representing an obvious extension of existing therapeutic management strategies
Source Patent Element
Pharmaceutical composition with fusion protein and anticancer agents
PTD Variation
Method for predicting treatment efficacy by analyzing cancer cell genetic biomarkers
Obviousness Reasoning
Biomarker-based treatment prediction is a standard technique in personalized oncology, representing a predictable application of genetic analysis to therapeutic selection
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857601 and the disclosed variations, a person having ordinary skill in the art would find the claimed personalized cancer treatment system with targeted fusion protein dimers and genetically tailored anticancer agents to be an obvious combination of known techniques in protein engineering, targeted drug delivery, and personalized medicine. The variations represent predictable extensions of the source patent's core technological framework, applying standard biotechnological optimization strategies to cancer therapeutic approaches.

Original Patent Information

Patent NumberUS 11,857,601
TitlePharmaceutical composition for cancer treatment comprising fusion protein including IL-2 protein and CD80 protein and anticancer drug
Assignee(s)GI Innovation, Inc.