Novel Bacteriocin Applications for Industrial and Environmental Uses

Publication ID: 24-11857606_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Novel Bacteriocin Applications for Industrial and Environmental Uses,” Published Technical Disclosure No. 24-11857606_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857606_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,606.

Summary of the Inventive Concept

This inventive concept leverages the core technology of therapeutic bacteriocins to address critical issues in industrial and environmental settings, including pipeline fouling, marine biofouling, food contamination, water treatment, and medical implant infections.

Background and Problem Solved

The original patent focused on therapeutic applications of bacteriocins to combat microbial infections. However, the core technology has broader potential. Industrial and environmental settings face significant challenges from biofilm-forming bacteria, which can cause corrosion, contamination, and compromised performance. Current solutions are often ineffective or environmentally harmful. This inventive concept addresses these limitations by applying bacteriocin technology to novel industries and use cases.

Detailed Description of the Inventive Concept

The new inventive concept involves the use of bacteriocins to target and kill bacteria responsible for biofilm formation, fouling, and contamination in various industrial and environmental settings. This includes pipeline systems, marine vessels, food processing facilities, water treatment systems, and medical implants. The bacteriocins are designed to reduce or eliminate biofilm formation, thereby improving fluid flow, reducing corrosion, and preventing contamination. The compositions and methods disclosed in the original patent are adapted and modified to accommodate the specific requirements of each new application.

Novelty and Inventive Step

The new inventive concept introduces a paradigm shift in the application of bacteriocin technology, moving beyond therapeutic uses to address critical industrial and environmental challenges. The inventive step lies in the recognition of the potential of bacteriocins to solve these specific problems and the development of novel compositions and methods tailored to each new use case.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different bacteriocin sequences, modified receptor-mediated translocation domains, or varying cargo domains to target specific bacterial strains or environments. Variations may also involve the combination of bacteriocins with other antimicrobial agents or surface coatings to enhance their effectiveness.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including oil and gas, marine, food processing, water treatment, and medical devices. The market size for these applications is substantial, with estimated values in the billions of dollars. The adoption of bacteriocin technology in these industries could lead to improved operational efficiency, reduced maintenance costs, and enhanced environmental sustainability.

CPC Classifications

SectionClassGroup
A A61 A61K38/43
A A01 A01N63/10
A A01 A01N63/50
C C07 C07K14/21
C C07 C07K14/26
C C12 C12N9/2462

Field of Art

Biotechnology and antimicrobial composition design, specifically focusing on bacteriocin engineering for targeted bacterial elimination across medical, industrial, and environmental applications

Person of Ordinary Skill (PHOSITA) Profile

A molecular biologist or biotechnology engineer with expertise in protein engineering, microbial interactions, and antimicrobial agent design, possessing advanced degrees and practical experience in manipulating bacteriocin structures and applications

Obviousness Rationale

A PHOSITA would recognize that the core bacteriocin technology from US 11857606 provides a versatile platform for targeting bacterial populations across multiple domains. The fundamental mechanism of receptor-mediated translocation and specific sequence targeting can be readily adapted to different environmental contexts with predictable antimicrobial outcomes. The disclosed variations represent logical extensions of the original bacteriocin technology by applying known protein engineering principles to solve specific industrial and environmental challenges.

Obvious Combinations & Variations

Source Patent Element
Bacteriocin with specific receptor-mediated translocation domain (SEQ ID NO:10, segments 1-320)
PTD Variation
Adapting bacteriocin for marine vessel hull biofouling prevention
Obviousness Reasoning
Known technique of surface modification using antimicrobial proteins, predictable result of reducing bacterial colonization through targeted protein engineering
Source Patent Element
Method of killing specific bacterial strains like Klebsiella pneumoniae and Escherichia coli
PTD Variation
Expanding bacterial targeting to industrial pipeline biofilm elimination
Obviousness Reasoning
Predictable extension of existing bacteriocin targeting mechanism to address similar bacterial elimination challenges in different environments
Source Patent Element
Bacteriocin with modular domain structure (translocation, receptor binding, cargo domains)
PTD Variation
Developing bacteriocin compositions for water treatment system bacterial control
Obviousness Reasoning
Routine application of known protein engineering principles to modify bacteriocin functionality for specific environmental contexts
Source Patent Element
Therapeutic bacteriocin targeting specific bacterial populations
PTD Variation
Applying bacteriocin technology to prevent medical implant infections
Obviousness Reasoning
Logical progression of existing antimicrobial technology using known protein modification techniques
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed herein would have been obvious to a person having ordinary skill in the art at the time of invention, as they represent predictable extensions of the bacteriocin technology disclosed in US Patent 11857606, utilizing standard protein engineering techniques to adapt a known antimicrobial mechanism to diverse industrial and environmental applications.

Original Patent Information

Patent NumberUS 11,857,606
TitleTherapeutic bacteriocins
Assignee(s)BACTOCLEAR HOLDINGS PTE. LTD.