Synergistic Combinations of Tissue Kallikrein 1 with AI, IoT, and Blockchain Technologies for Enhanced Ischemic Condition Treatment

Publication ID: 24-11857608_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Combinations of Tissue Kallikrein 1 with AI, IoT, and Blockchain Technologies for Enhanced Ischemic Condition Treatment,” Published Technical Disclosure No. 24-11857608_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857608_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,608.

Summary of the Inventive Concept

The present inventive concept integrates tissue kallikrein 1 dosage forms with cutting-edge technologies like AI, IoT, and blockchain to create a powerful system for treating ischemic conditions, offering enhanced efficacy, personalized treatment, and secure data management.

Background and Problem Solved

The original patent disclosed dosage forms of tissue kallikrein 1 for treating ischemic conditions. However, these forms had limitations in terms of efficacy, patient monitoring, and data security. The present inventive concept addresses these limitations by incorporating AI, IoT, and blockchain technologies to create a more comprehensive and effective treatment system.

Detailed Description of the Inventive Concept

The synergistic combinations disclosed herein comprise tissue kallikrein 1 dosage forms integrated with AI-powered monitoring modules, IoT-enabled sensors, and blockchain-based data storage units. These components work together to provide real-time monitoring of patient responses, personalized treatment plans, and secure recording of treatment outcomes. The AI-powered monitoring module analyzes patient data and generates customized treatment plans. The IoT-enabled sensor tracks dosage efficacy and provides real-time feedback. The blockchain-based data storage unit ensures secure and tamper-proof recording of treatment outcomes.

Novelty and Inventive Step

The integration of tissue kallikrein 1 dosage forms with AI, IoT, and blockchain technologies is new and non-obvious compared to the original patent. The synergistic combinations disclosed herein provide a unique and effective solution for treating ischemic conditions, overcoming the limitations of the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include the use of different AI algorithms, IoT-enabled devices, or blockchain-based platforms. Variations may also include the integration of additional technologies, such as machine learning or cloud-based data analytics, to further enhance the system's capabilities.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in the pharmaceutical and healthcare industries, particularly in the treatment of ischemic conditions. The system's enhanced efficacy, personalized treatment, and secure data management capabilities make it an attractive solution for patients, healthcare providers, and pharmaceutical companies.

CPC Classifications

SectionClassGroup
A A61 A61K38/4853
A A61 A61K9/0019
A A61 A61K45/06
C C12 C12Y304/21035

Field of Art

Pharmaceutical biotechnology, specifically drug delivery systems and treatment methods for ischemic conditions, involving protein therapeutics and advanced medical technologies

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or pharmaceutical scientist with expertise in protein formulation, medical device integration, data analytics, and personalized medicine technologies, holding advanced degrees and practical experience in translating biological discoveries into clinical applications

Obviousness Rationale

A person having ordinary skill in the art would recognize that integrating advanced monitoring and data management technologies with existing tissue kallikrein 1 dosage forms represents a predictable extension of known medical technology trends. The combination of AI, IoT, and blockchain with established pharmaceutical delivery methods follows standard technological convergence patterns in personalized medicine. A PHOSITA would understand that enhancing drug delivery with real-time monitoring and secure data management is a logical progression in treatment optimization strategies.

Obvious Combinations & Variations

Source Patent Element
Subcutaneous and intravenous administration of tissue kallikrein 1 dosage forms for treating ischemic conditions
PTD Variation
Adding IoT-enabled sensors for real-time monitoring of dosage efficacy and patient response
Obviousness Reasoning
Integrating monitoring technologies with drug delivery is a known technique in personalized medicine, representing a predictable application of existing technological capabilities
Source Patent Element
Treatment methods targeting specific ischemic conditions like brain and cardiac ischemia
PTD Variation
Implementing AI-powered analytics to generate customized treatment plans based on patient-specific data
Obviousness Reasoning
Personalized medicine approaches using machine learning for treatment optimization are well-established in the medical technology field, representing an obvious technological progression
Source Patent Element
Dosage forms of tissue kallikrein 1 polypeptides
PTD Variation
Blockchain-based secure data storage and authentication mechanisms for treatment records
Obviousness Reasoning
Applying blockchain security technologies to medical record management is a known solution for addressing data integrity and patient privacy concerns
Source Patent Element
Therapeutic serum levels of KLK1 polypeptides
PTD Variation
Cloud-based data analytics platforms for tracking and optimizing treatment outcomes
Obviousness Reasoning
Remote monitoring and data analysis platforms are standard technological approaches for improving medical treatment efficacy and patient management
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857608 and the present published technical disclosure, a person having ordinary skill in the art would find obvious the integration of advanced monitoring technologies with tissue kallikrein 1 dosage forms. The disclosed variations represent predictable combinations of known medical technologies, demonstrating that the claimed innovations would have been obvious to a skilled practitioner at the time of invention.

Original Patent Information

Patent NumberUS 11,857,608
TitleDosage forms of tissue kallikrein 1
Assignee(s)DiaMedica Inc.