Tissue Kallikrein 1-Based Formulations for Agricultural and Environmental Applications
Legal Citation
Summary of the Inventive Concept
This inventive concept leverages the core technology of tissue kallikrein 1 (KLK1) polypeptides to develop innovative solutions for agricultural and environmental challenges, including crop growth enhancement, soil erosion prevention, wildfire prevention, and water quality improvement.
Background and Problem Solved
The original patent disclosed dosage forms of tissue kallikrein 1 for treating ischemic conditions. However, the limitations of this technology in addressing agricultural and environmental issues prompted the development of new applications and use cases. The inventive concept addresses the need for sustainable and effective solutions in these fields.
Detailed Description of the Inventive Concept
The new claims describe systems, methods, and compositions that utilize KLK1-based formulations to enhance plant growth and stress resistance, reduce soil erosion, predict and prevent wildfires, and improve water quality. These formulations can be administered through various means, including subcutaneous or intravenous injection, and can be monitored using sensor systems. The KLK1 polypeptides interact with plant cells to stimulate growth and increase resistance to environmental stressors, while also reducing vegetation water content to prevent wildfires.
Novelty and Inventive Step
The new claims introduce a paradigm shift in the application of KLK1 technology, moving from ischemic condition treatment to agricultural and environmental solutions. The inventive step lies in the recognition of KLK1's potential in these new fields and the development of formulations and systems that effectively address specific challenges.
Alternative Embodiments and Variations
Alternative embodiments may include different KLK1 polypeptide formulations, varying administration methods, and diverse sensor systems for monitoring crop growth and stress levels. Variations may also involve integrating KLK1 technology with existing agricultural and environmental practices to create hybrid solutions.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in the agricultural and environmental industries, with potential applications in crop enhancement, soil conservation, wildfire prevention, and water quality management. The target market includes agricultural companies, environmental organizations, and government agencies seeking sustainable and effective solutions to pressing challenges.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K38/4853 |
| A | A61 | A61K9/0019 |
| A | A61 | A61K45/06 |
| C | C12 | C12Y304/21035 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biotechnology and pharmaceutical formulations, specifically protein-based therapeutic and agricultural compositions, with expertise in polypeptide delivery systems and biological interactions
Person of Ordinary Skill (PHOSITA) Profile
A professional with advanced degrees in biotechnology, biochemistry, or chemical engineering, having knowledge of protein engineering, drug delivery mechanisms, and cross-disciplinary applications of biological molecules
Obviousness Rationale
A PHOSITA would recognize the inherent versatility of KLK1 polypeptides based on the source patent's detailed characterization of protein interactions and delivery mechanisms. The agricultural and environmental applications represent a predictable extension of the protein's known biological properties, utilizing established biotechnological techniques for repurposing therapeutic molecules. The sensor-based monitoring and varied administration methods are consistent with standard biotechnological approaches to developing multi-functional biological systems.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,608 |
|---|---|
| Title | Dosage forms of tissue kallikrein 1 |
| Assignee(s) | DiaMedica Inc. |