Synergistic Tissue Kallikrein 1 Systems for Personalized Ischemic Condition Treatment

Publication ID: 24-11857608_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Tissue Kallikrein 1 Systems for Personalized Ischemic Condition Treatment,” Published Technical Disclosure No. 24-11857608_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857608_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,608.

Summary of the Inventive Concept

This inventive concept integrates dosage forms of tissue kallikrein 1 with distinct technologies such as AI, IoT, blockchain, and nanomaterials to create a more powerful system for treating ischemic conditions, enabling personalized dosage optimization, real-time monitoring, and secure data storage.

Background and Problem Solved

The original patent disclosed dosage forms of tissue kallikrein 1 for treating ischemic conditions, but it had limitations in terms of personalized treatment and data management. This inventive concept addresses these limitations by combining the patented dosage forms with advanced technologies to create a more effective and efficient system.

Detailed Description of the Inventive Concept

The system comprises a dosage form of tissue kallikrein 1, an artificial intelligence module for personalized dosage optimization, IoT-enabled sensors for real-time monitoring, a blockchain-based decentralized data storage module for secure storage and sharing of medical records, and a nanomaterial-based sensor array for wearable devices. The AI module analyzes patient data and optimizes dosage, while the IoT sensors track treatment efficacy and the blockchain module ensures secure data storage. The wearable device enables real-time monitoring, and the nanomaterial-based sensor array enhances sensitivity and accuracy.

Novelty and Inventive Step

The new claims introduce the synergistic combination of dosage forms of tissue kallikrein 1 with AI, IoT, blockchain, and nanomaterials, which is not obvious from the original patent. The inventive step lies in the integration of these distinct technologies to create a more powerful system for treating ischemic conditions.

Alternative Embodiments and Variations

Alternative embodiments may include integrating the dosage forms with other AI algorithms, using different IoT sensors or blockchain platforms, or incorporating other nanomaterials or wearable devices. Variations may include using the system for treating other conditions, such as cancer or inflammatory diseases.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential in the pharmaceutical and healthcare industries, particularly in the areas of personalized medicine, telemedicine, and digital health. The target market includes hospitals, clinics, and research institutions, as well as patients and healthcare providers.

CPC Classifications

SectionClassGroup
A A61 A61K38/4853
A A61 A61K9/0019
A A61 A61K45/06
C C12 C12Y304/21035

Field of Art

Pharmaceutical biotechnology, specifically focused on tissue kallikrein 1 (KLK1) dosage forms for treating ischemic conditions, involving drug delivery systems, personalized medicine technologies, and medical monitoring techniques

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or pharmaceutical scientist with expertise in protein therapeutics, drug delivery systems, medical device integration, and digital health technologies, holding advanced degrees and practical experience in translating biological research into clinical applications

Obviousness Rationale

A PHOSITA would recognize that integrating digital health technologies with existing therapeutic approaches represents a natural progression in personalized medicine. The combination of KLK1 dosage forms with AI, IoT, and monitoring technologies follows established patterns of technological convergence in medical treatment. The disclosed variations represent predictable extensions of known techniques for enhancing therapeutic monitoring and personalization.

Obvious Combinations & Variations

Source Patent Element
Subcutaneous and intravenous administration of KLK1 polypeptides for treating ischemic conditions
PTD Variation
Adding AI-driven dosage optimization algorithms to personalize KLK1 administration
Obviousness Reasoning
Personalized medicine and adaptive dosing are well-established techniques in pharmaceutical research, making algorithmic optimization a predictable enhancement to existing drug delivery methods
Source Patent Element
Therapeutic serum levels of KLK1 polypeptides for treating ischemic conditions
PTD Variation
Implementing IoT-enabled sensors for real-time monitoring of treatment efficacy
Obviousness Reasoning
Continuous patient monitoring is a known approach in medical technology, and integrating sensors with existing therapeutic protocols represents a logical technological progression
Source Patent Element
Method of treating ischemic conditions using KLK1 polypeptides
PTD Variation
Blockchain-based secure medical record storage and blockchain-enabled treatment tracking
Obviousness Reasoning
Secure medical data management is a recognized challenge in healthcare, and blockchain represents a known solution for addressing data integrity and patient privacy concerns
Source Patent Element
Dosage forms of tissue kallikrein 1 for treating specific ischemic conditions
PTD Variation
Nanomaterial-based sensor arrays for enhanced monitoring and treatment sensitivity
Obviousness Reasoning
Nanomaterial integration in medical devices is a well-established trend, and using advanced sensing technologies to improve treatment monitoring represents a predictable technological enhancement
Source Patent Element
Therapeutic administration of KLK1 polypeptides
PTD Variation
Machine learning algorithms for predicting treatment outcomes and personalizing interventions
Obviousness Reasoning
Predictive analytics in medical treatment is a recognized approach, and applying machine learning to existing therapeutic protocols represents a standard technological evolution
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857608 and the disclosed technological variations, a person having ordinary skill in the art would find the integration of digital health technologies with KLK1 dosage forms to be an obvious extension of existing pharmaceutical and medical monitoring techniques. The combination of known elements produces predictable results in the field of personalized medical treatment, thereby rendering potential claims covering such variations obvious and unpatentable.

Original Patent Information

Patent NumberUS 11,857,608
TitleDosage forms of tissue kallikrein 1
Assignee(s)DiaMedica Inc.