Synergistic Tissue Kallikrein 1 Systems for Personalized Ischemic Condition Treatment

Publication ID: 24-11857608_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Tissue Kallikrein 1 Systems for Personalized Ischemic Condition Treatment,” Published Technical Disclosure No. 24-11857608_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857608_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,608.

Summary of the Inventive Concept

This inventive concept integrates dosage forms of tissue kallikrein 1 with distinct technologies such as AI, IoT, blockchain, and nanomaterials to create a more powerful system for treating ischemic conditions, enabling personalized dosage optimization, real-time monitoring, and secure data storage.

Background and Problem Solved

The original patent disclosed dosage forms of tissue kallikrein 1 for treating ischemic conditions, but it had limitations in terms of personalized treatment and data management. This inventive concept addresses these limitations by combining the patented dosage forms with advanced technologies to create a more effective and efficient system.

Detailed Description of the Inventive Concept

The system comprises a dosage form of tissue kallikrein 1, an artificial intelligence module for personalized dosage optimization, IoT-enabled sensors for real-time monitoring, a blockchain-based decentralized data storage module for secure storage and sharing of medical records, and a nanomaterial-based sensor array for wearable devices. The AI module analyzes patient data and optimizes dosage, while the IoT sensors track treatment efficacy and the blockchain module ensures secure data storage. The wearable device enables real-time monitoring, and the nanomaterial-based sensor array enhances sensitivity and accuracy.

Novelty and Inventive Step

The new claims introduce the synergistic combination of dosage forms of tissue kallikrein 1 with AI, IoT, blockchain, and nanomaterials, which is not obvious from the original patent. The inventive step lies in the integration of these distinct technologies to create a more powerful system for treating ischemic conditions.

Alternative Embodiments and Variations

Alternative embodiments may include integrating the dosage forms with other AI algorithms, using different IoT sensors or blockchain platforms, or incorporating other nanomaterials or wearable devices. Variations may include using the system for treating other conditions, such as cancer or inflammatory diseases.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential in the pharmaceutical and healthcare industries, particularly in the areas of personalized medicine, telemedicine, and digital health. The target market includes hospitals, clinics, and research institutions, as well as patients and healthcare providers.

CPC Classifications

SectionClassGroup
A A61 A61K38/4853
A A61 A61K9/0019
A A61 A61K45/06
C C12 C12Y304/21035

Original Patent Information

Patent NumberUS 11,857,608
TitleDosage forms of tissue kallikrein 1
Assignee(s)DiaMedica Inc.