Synergistic Bladder Cancer Treatment System

Publication ID: 24-11857612_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Bladder Cancer Treatment System,” Published Technical Disclosure No. 24-11857612_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857612_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,612.

Summary of the Inventive Concept

A comprehensive system integrating antigen presenting cells, IL-15 based superagonists, and cutting-edge technologies like blockchain, AI, and IoT to revolutionize bladder cancer treatment by enhancing immune response, monitoring patient outcomes, and predicting treatment efficacy.

Background and Problem Solved

The original patent disclosed a vaccine composition for treating bladder cancer using antigen presenting cells and IL-15 based superagonists. However, it lacked a comprehensive system for tracking patient response, predicting treatment outcomes, and optimizing the immune response. The new inventive concept addresses these limitations by synergistically combining the patented vaccine composition with advanced technologies to create a more powerful and effective treatment system.

Detailed Description of the Inventive Concept

The Synergistic Bladder Cancer Treatment System consists of a composition including antigen presenting cells isolated from a subject treated with Bacillus Calmette-Guerin (BCG) and cultured with IL-15 based superagonists. This composition is integrated with a blockchain-based tracking module for monitoring patient response to the composition, ensuring secure and transparent data management. Additionally, the system incorporates artificial intelligence (AI) to predict and optimize the immune response, and a sensor-enabled device for monitoring the patient's immune response and transmitting data to a cloud-based server for analysis. The system also includes a machine learning algorithm trained on data from patients treated with the composition, enabling the prediction of patient response to bladder cancer treatment.

Novelty and Inventive Step

The new claims introduce the innovative combination of the patented vaccine composition with blockchain, AI, IoT, and machine learning technologies, providing a novel and non-obvious solution for treating bladder cancer. The integration of these technologies enables a more effective and personalized treatment approach, overcoming the limitations of the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the Synergistic Bladder Cancer Treatment System could include the use of different types of antigen presenting cells, varying IL-15 based superagonist formulations, or the integration of other advanced technologies like nanotechnology or gene editing. These variations would ensure broad conceptual coverage and adaptability to different treatment scenarios.

Potential Commercial Applications and Market

The Synergistic Bladder Cancer Treatment System has significant commercial potential in the oncology market, particularly in the treatment of bladder cancer. The system's ability to enhance immune response, monitor patient outcomes, and predict treatment efficacy could lead to improved patient survival rates, reduced healthcare costs, and increased market share for NantCell, Inc.

CPC Classifications

SectionClassGroup
A A61 A61K39/04
A A61 A61K35/15
A A61 A61K39/00114
A A61 A61K39/001119
A A61 A61K39/39
A A61 A61K2039/515
A A61 A61K2039/585

Original Patent Information

Patent NumberUS 11,857,612
TitleBacillus Calmette-Guerin (BCG) and antigen presenting cells for treatment of bladder cancer
Assignee(s)NantCell, Inc.