Adaptive Bladder Cancer Treatment Solutions for Niche Environments
Legal Citation
Summary of the Inventive Concept
This inventive concept adapts the original Bacillus Calmette-Guerin (BCG) and antigen presenting cells treatment for bladder cancer to address specific, high-need niches, including high-altitude, high-security, disaster relief, extreme weather, and remote area settings.
Background and Problem Solved
The original patent's treatment approach, while effective, has limitations in terms of adaptability to unique operational environments. This inventive concept addresses these limitations by providing specialized variations and niche solutions, enabling effective treatment of bladder cancer in diverse settings.
Detailed Description of the Inventive Concept
The inventive concept encompasses four primary aspects: 1) high-altitude treatment, where the vaccine composition is formulated to withstand lower oxygen levels; 2) high-security treatment, where antigen presenting cells are cultured in a secure, isolated facility; 3) disaster relief treatment, featuring a portable device for isolating and culturing antigen presenting cells; and 4) extreme weather and remote area treatment, where the vaccine composition is formulated to withstand extreme temperatures and the kit includes a portable device for isolating and culturing antigen presenting cells. These adaptations ensure the treatment remains effective in diverse environments.
Novelty and Inventive Step
The new claims introduce novel adaptations of the original treatment approach, including the use of specialized formulations, portable devices, and secure facilities, which are not obvious from the original patent. These adaptations enable the treatment to be effective in niche environments, providing a non-obvious solution to the problem of limited adaptability.
Alternative Embodiments and Variations
Alternative embodiments could include using different IL-15:IL-15Rα fusion protein complexes, varying the antigen presenting cell isolation and culturing methods, or incorporating additional components to enhance treatment efficacy. Variations could also include adapting the treatment for other types of cancer or diseases.
Potential Commercial Applications and Market
This inventive concept has significant commercial potential in the biotechnology and pharmaceutical industries, particularly in the areas of cancer treatment and immunotherapy. The niche solutions provided could be marketed to organizations operating in high-altitude, high-security, disaster relief, extreme weather, and remote area settings, such as military organizations, humanitarian groups, and remote healthcare providers.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K39/04 |
| A | A61 | A61K35/15 |
| A | A61 | A61K39/00114 |
| A | A61 | A61K39/001119 |
| A | A61 | A61K39/39 |
| A | A61 | A61K2039/515 |
| A | A61 | A61K2039/585 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Immunotherapy and cancer treatment, specifically focusing on bladder cancer immunotherapeutic approaches involving antigen presenting cells and cytokine complexes
Person of Ordinary Skill (PHOSITA) Profile
A skilled practitioner with expertise in immunology, cell biology, and cancer treatment, holding a PhD or equivalent advanced degree, with working knowledge of cell isolation techniques, immunotherapeutic strategies, and adaptive vaccine development
Obviousness Rationale
A person having ordinary skill would recognize that adapting the core BCG-based immunotherapeutic approach to different environmental contexts represents a predictable engineering variation. The fundamental immunological mechanism remains consistent, with the PTD merely extending the treatment's applicability through targeted formulation and isolation strategies. These modifications represent logical extensions of the source patent's core technological principles.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,612 |
|---|---|
| Title | Bacillus Calmette-Guerin (BCG) and antigen presenting cells for treatment of bladder cancer |
| Assignee(s) | NantCell, Inc. |