Integrative Bladder Cancer Treatment Platform

Publication ID: 24-11857612_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Integrative Bladder Cancer Treatment Platform,” Published Technical Disclosure No. 24-11857612_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857612_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,612.

Summary of the Inventive Concept

A comprehensive system integrating antigen presenting cells, IL-15 based superagonists, and cutting-edge technologies like blockchain, AI, IoT, and nanomaterials to revolutionize bladder cancer treatment and patient care.

Background and Problem Solved

The original patent disclosed a vaccine composition for treating bladder cancer using antigen presenting cells and IL-15 based superagonists. However, this invention had limitations in tracking patient treatment and response, predicting treatment outcomes, and ensuring secure data storage and sharing. The new inventive concept addresses these limitations by integrating distinct technologies to create a more powerful and efficient system.

Detailed Description of the Inventive Concept

The integrative platform comprises a composition including antigen presenting cells isolated from a subject treated with Bacillus Calmette-Guerin (BCG) and cultured with IL-15 based superagonists. This composition is administered to bladder cancer patients and tracked using a blockchain-based platform, which ensures secure data storage and sharing. Artificial intelligence is used to analyze patient data and predict treatment outcomes, while an IoT network enables remote monitoring and control of devices delivering the composition. Additionally, a machine learning model is trained on patient data to predict treatment outcomes, and a nanomaterial-based delivery system targets the composition to bladder cancer cells.

Novelty and Inventive Step

The new inventive concept's novelty lies in the synergistic integration of antigen presenting cells, IL-15 based superagonists, and distinct technologies like blockchain, AI, IoT, and nanomaterials. This integration provides a non-obvious solution to the limitations of the original patent, enabling a more efficient, secure, and effective treatment of bladder cancer.

Alternative Embodiments and Variations

Alternative embodiments may include using different types of immunotherapeutic primed antigen presenting cells, varying the IL-15 based superagonist complex, or incorporating other emerging technologies like quantum computing or bioprinting. Variations may also involve adapting the platform for treating other types of cancer or diseases.

Potential Commercial Applications and Market

The integrative bladder cancer treatment platform has significant commercial potential in the oncology and healthcare industries, with a target market including hospitals, research institutions, and pharmaceutical companies. The platform's ability to enhance treatment outcomes, reduce costs, and ensure secure data storage and sharing makes it an attractive solution for stakeholders in the healthcare ecosystem.

CPC Classifications

SectionClassGroup
A A61 A61K39/04
A A61 A61K35/15
A A61 A61K39/00114
A A61 A61K39/001119
A A61 A61K39/39
A A61 A61K2039/515
A A61 A61K2039/585

Original Patent Information

Patent NumberUS 11,857,612
TitleBacillus Calmette-Guerin (BCG) and antigen presenting cells for treatment of bladder cancer
Assignee(s)NantCell, Inc.