Integrated Vaccine and IoT-Blockchain-AI System for Necrotic Enteritis Prevention in Poultry

Publication ID: 24-11857613_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Integrated Vaccine and IoT-Blockchain-AI System for Necrotic Enteritis Prevention in Poultry,” Published Technical Disclosure No. 24-11857613_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857613_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,613.

Summary of the Inventive Concept

A synergistic combination of a plant-based vaccine containing a PlcC-NetB fusion protein with IoT, blockchain, AI, and nanocarrier technologies to prevent necrotic enteritis in poultry, enabling real-time monitoring, secure tracking, and optimized vaccination processes.

Background and Problem Solved

Necrotic enteritis is a significant disease affecting poultry worldwide, causing substantial economic losses. The original patent disclosed a vaccine for prevention of necrotic enteritis in poultry, but it lacked the integration of advanced technologies to enhance its effectiveness. The new inventive concept addresses this limitation by combining the vaccine with IoT, blockchain, AI, and nanocarrier technologies to provide a comprehensive solution for necrotic enteritis prevention.

Detailed Description of the Inventive Concept

The integrated system consists of a plant-based vaccine containing a PlcC-NetB fusion protein, which is administered to poultry to prevent necrotic enteritis. The vaccine is combined with an IoT-enabled monitoring device that tracks poultry health and detects early signs of infection. The vaccination process is secured and tracked using blockchain technology, ensuring transparency and accountability. An AI-powered diagnostic tool is used to identify infected poultry and predict the risk of disease outbreaks. The vaccine is delivered using a nanocarrier system, which targets the gut of the poultry, enhancing its efficacy.

Novelty and Inventive Step

The new claims introduce a synergistic combination of advanced technologies, including IoT, blockchain, AI, and nanocarrier systems, which are not present in the original patent. The integration of these technologies with the vaccine provides a novel and non-obvious solution for necrotic enteritis prevention in poultry.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include the use of different types of vaccines, such as mRNA-based vaccines, or the integration of other advanced technologies, such as robotics or machine learning algorithms, to enhance the system's effectiveness. Variations of the system may be designed for use in different poultry production settings, such as large-scale industrial farms or small-scale backyard farms.

Potential Commercial Applications and Market

The integrated vaccine and IoT-blockchain-AI system has significant commercial potential in the poultry industry, which is a multi-billion-dollar market. The system can be marketed to poultry producers, veterinarians, and animal health companies, offering a comprehensive solution for necrotic enteritis prevention and enhancing animal welfare.

CPC Classifications

SectionClassGroup
A A61 A61K39/08
A A61 A61P31/04
C C12 C12N15/74
C C12 C12N15/8258
A A61 A61K2039/552
A A61 A61K2039/55577

Field of Art

Veterinary biotechnology, specifically vaccine development for poultry diseases, involving molecular biology, protein engineering, and infectious disease prevention

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in veterinary science or molecular biology, experienced in protein fusion techniques, vaccine design, and understanding of bacterial pathogenesis in poultry

Obviousness Rationale

A PHOSITA would recognize that integrating advanced monitoring and delivery technologies with the existing PlcC-NetB fusion vaccine represents a predictable extension of known vaccine development strategies. The combination of IoT, blockchain, and AI technologies with established vaccine platforms is a logical progression in precision veterinary medicine. The technical elements disclosed in the PTD represent incremental improvements that would be obvious to a skilled practitioner seeking to enhance vaccine efficacy and tracking.

Obvious Combinations & Variations

Source Patent Element
PlcC-NetB fusion protein for preventing C. perfringens infection
PTD Variation
Plant-based expression of the fusion protein with nanocarrier delivery system
Obviousness Reasoning
Expression of recombinant proteins in plant systems is a known technique, and targeted nanocarrier delivery represents a predictable optimization of vaccine administration
Source Patent Element
Vaccine targeting C. perfringens in poultry
PTD Variation
IoT and blockchain tracking of vaccination process
Obviousness Reasoning
Implementing digital tracking for biological interventions is a standard approach in modern veterinary and agricultural technologies
Source Patent Element
Protein sequence with specific amino acid modifications
PTD Variation
AI-powered diagnostic tool for predicting disease outbreak risks
Obviousness Reasoning
Machine learning applied to infectious disease prediction is a well-established approach in epidemiological research
Source Patent Element
Vaccine composition for preventing necrotic enteritis
PTD Variation
Integration of machine learning algorithms in vaccine production optimization
Obviousness Reasoning
Computational optimization of biological production processes is a known technique in biotechnology
Source Patent Element
Protein fusion approach for immunological protection
PTD Variation
mRNA-based vaccine alternative using similar protein targeting
Obviousness Reasoning
Alternative vaccine platforms targeting the same molecular mechanisms represent a predictable technological variation
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed in this Published Technical Disclosure would be obvious to a Person Having Ordinary Skill In The Art based on US Patent 11857613, as the technical combinations represent predictable extensions of known vaccine development and digital tracking technologies in veterinary medicine, with no evidence of unexpected results or non-obvious technical achievements.

Original Patent Information

Patent NumberUS 11,857,613
TitleVaccine for prevention of necrotic enteritis in poultry
Assignee(s)Arizona Board of Regents on Behalf of Arizona State University