Next-Generation Necrotic Enteritis Vaccine System

Publication ID: 24-11857613_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Next-Generation Necrotic Enteritis Vaccine System,” Published Technical Disclosure No. 24-11857613_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857613_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,613.

Summary of the Inventive Concept

A pioneering vaccine system for necrotic enteritis in poultry, leveraging plant-based expression, nanocapsule delivery, and AI-driven development to provide unparalleled protection against C. perfringens infection.

Background and Problem Solved

The original patent's vaccine composition, while effective, has limitations in terms of production scalability, delivery efficiency, and adaptability to emerging strains. This new inventive concept addresses these limitations by introducing a novel, plant-based expression system for producing fusion proteins, a slow-release nanocapsule delivery system, and AI-driven development to accelerate vaccine development and enhance efficacy.

Detailed Description of the Inventive Concept

The new inventive concept comprises a plant-based expression system engineered to produce a PlcC-NetB fusion protein, which is then administered to poultry in a slow-release, nanocapsule-based delivery system. This system enables prolonged protection against C. perfringens infection. Additionally, the inventive concept incorporates an AI-driven development platform to identify optimal antigen combinations and adjuvants, thereby accelerating the development of effective vaccines. The system also includes a wearable device for monitoring the bird's health status, coupled with a machine learning algorithm to predict the likelihood of C. perfringens infection, enabling early intervention and prevention.

Novelty and Inventive Step

The new claims introduce a paradigm shift in necrotic enteritis vaccine development by integrating plant-based expression, nanocapsule delivery, and AI-driven development. These novel elements provide a significant improvement over the original patent's composition, offering enhanced efficacy, scalability, and adaptability.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include using different plant-based expression systems, varying the composition of the nanocapsule delivery system, or incorporating additional AI-driven tools for vaccine development and monitoring. These variations would ensure broad conceptual coverage and adaptability to diverse poultry production settings.

Potential Commercial Applications and Market

The next-generation necrotic enteritis vaccine system has significant commercial potential in the poultry industry, with potential applications in vaccine development, production, and distribution. The target market includes poultry farmers, vaccine manufacturers, and animal health companies seeking to improve bird health and reduce mortality rates.

CPC Classifications

SectionClassGroup
A A61 A61K39/08
A A61 A61P31/04
C C12 C12N15/74
C C12 C12N15/8258
A A61 A61K2039/552
A A61 A61K2039/55577

Original Patent Information

Patent NumberUS 11,857,613
TitleVaccine for prevention of necrotic enteritis in poultry
Assignee(s)Arizona Board of Regents on Behalf of Arizona State University