Synergistic Vaccine System for Necrotic Enteritis Prevention in Poultry

Publication ID: 24-11857613_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Vaccine System for Necrotic Enteritis Prevention in Poultry,” Published Technical Disclosure No. 24-11857613_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857613_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,613.

Summary of the Inventive Concept

A comprehensive system integrating a novel vaccine, blockchain, IoT, AI, and plant-based delivery to prevent necrotic enteritis in poultry, providing real-time monitoring, data-driven decision making, and optimized vaccine distribution.

Background and Problem Solved

The original patent addressed the limitations of existing vaccines for necrotic enteritis in poultry, but lacked a comprehensive system for prevention and control. This new inventive concept integrates distinct technologies to create a powerful system that overcomes the limitations of the original patent.

Detailed Description of the Inventive Concept

The system comprises a blockchain-based vaccine tracking module, a cloud-based data analytics platform, and a machine learning algorithm for predicting disease outbreaks. The vaccine is administered orally through a plant-based delivery system comprising a fusion protein combining immunogenic and non-toxic components of alpha-toxin and NetB. IoT sensors track environmental conditions, and AI-powered image recognition detects disease symptoms. The vaccine is delivered through a drone-based system, and the blockchain-based supply chain management system optimizes vaccine distribution.

Novelty and Inventive Step

The new claims introduce a synergistic combination of technologies, including blockchain, IoT, AI, and plant-based delivery, which are not present in the original patent. The inventive step lies in the integration of these technologies to create a comprehensive system for necrotic enteritis prevention and control.

Alternative Embodiments and Variations

Alternative embodiments may include using different types of sensors, machine learning algorithms, or blockchain platforms. Variations may include adapting the system for use in different poultry production settings or integrating additional technologies, such as robotics or nanotechnology.

Potential Commercial Applications and Market

The synergistic vaccine system has significant commercial potential in the poultry industry, with potential applications in disease prevention and control, supply chain management, and data-driven decision making. The target market includes poultry producers, veterinarians, and animal health companies.

CPC Classifications

SectionClassGroup
A A61 A61K39/08
A A61 A61P31/04
C C12 C12N15/74
C C12 C12N15/8258
A A61 A61K2039/552
A A61 A61K2039/55577

Field of Art

Veterinary biotechnology, specifically poultry vaccine development and disease prevention technologies involving molecular biology, immunology, and agricultural biotechnology

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in veterinary science or molecular biology, familiar with protein engineering, vaccine design, biotechnology platforms, and agricultural disease management strategies

Obviousness Rationale

A PHOSITA would recognize that integrating digital technologies like blockchain, IoT, and AI with existing vaccine technologies represents a predictable extension of known approaches to disease management. The core vaccine technology remains fundamentally similar to the source patent's PlcC-NetB fusion protein concept, with additional technological monitoring and delivery systems that are well-established in the field. The variations represent incremental improvements using standard technological integration techniques available to skilled practitioners.

Obvious Combinations & Variations

Source Patent Element
PlcC-NetB fusion protein for preventing C. perfringens infection
PTD Variation
Plant-based production of PlcC-NetB fusion protein with blockchain tracking and drone delivery
Obviousness Reasoning
Plant-based protein production and alternative delivery methods are known techniques in biotechnology, representing a predictable variation of existing vaccine development strategies
Source Patent Element
Vaccine targeting C. perfringens in poultry
PTD Variation
AI-powered image recognition and IoT sensor monitoring for disease detection
Obviousness Reasoning
Integrating digital monitoring technologies with veterinary health management is a standard approach for improving disease prevention and tracking
Source Patent Element
Protein-based vaccine targeting specific bacterial proteins
PTD Variation
Machine learning algorithm for predicting disease outbreaks based on environmental data
Obviousness Reasoning
Predictive analytics and machine learning are well-established techniques for analyzing complex biological systems and disease patterns
Source Patent Element
Immunogenic protein components for preventing bacterial infection
PTD Variation
Blockchain-based supply chain management for vaccine distribution
Obviousness Reasoning
Blockchain tracking represents a standard technological enhancement for improving logistics and traceability in biotechnology product distribution
Source Patent Element
NetB protein targeting C. perfringens
PTD Variation
Cloud-based data analytics platform for comprehensive disease management
Obviousness Reasoning
Cloud computing and centralized data platforms are standard technological solutions for integrating and analyzing complex biological and environmental datasets
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed in this publication would be obvious to a person having ordinary skill in the art at the time of invention, as they represent predictable combinations of known technologies extending the foundational vaccine methodology disclosed in US Patent 11857613, utilizing standard biotechnological integration techniques without requiring inventive complexity.

Original Patent Information

Patent NumberUS 11,857,613
TitleVaccine for prevention of necrotic enteritis in poultry
Assignee(s)Arizona Board of Regents on Behalf of Arizona State University