Flagellin Polypeptides for Diverse Applications

Publication ID: 24-11857614_0002_PTD

Published: October 28, 2025

Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Flagellin Polypeptides for Diverse Applications,” Published Technical Disclosure No. 24-11857614_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857614_0002_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,614.

Summary of the Inventive Concept

This inventive concept explores the application of Enterococcus gallinarum flagellin polypeptides in novel industries and use cases, leveraging their immunomodulatory properties to stimulate defense responses and improve outcomes in agriculture, bioremediation, cosmetics, veterinary care, and biodegradable packaging.

Background and Problem Solved

The original patent focused on pharmaceutical compositions for treating diseases. However, the immunomodulatory properties of Enterococcus gallinarum flagellin polypeptides have broader potential. This inventive concept addresses the limitation of the original patent by exploring new applications and use cases, solving the problem of underutilization of these polypeptides.

Detailed Description of the Inventive Concept

The new claims introduce novel applications of Enterococcus gallinarum flagellin polypeptides. For instance, in agriculture, these polypeptides can be used to stimulate plant defense responses, increasing crop yields and resistance to pathogens. In bioremediation, they can enhance microbial activity, promoting the degradation of pollutants in contaminated soil. In cosmetics, they can stimulate skin defense responses, improving skin health. In veterinary care, they can stimulate immune responses, preventing disease in animals. Finally, in biodegradable packaging, they can inhibit microbial growth, extending the shelf life of packaged products.

Novelty and Inventive Step

The new claims introduce a paradigm shift in the application of Enterococcus gallinarum flagellin polypeptides, moving from pharmaceutical compositions to diverse industries and use cases. This inventive concept is novel and non-obvious, as it requires a deep understanding of the polypeptides' immunomodulatory properties and their potential in new applications.

Alternative Embodiments and Variations

Alternative embodiments of this inventive concept could include using different bacterial strains or modifying the flagellin polypeptides to enhance their efficacy. Variations could also include combining these polypeptides with other compounds or technologies to create synergistic effects.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential, as it addresses pressing needs in various industries. The market for these applications is substantial, with potential customers including agricultural companies, bioremediation service providers, cosmetic manufacturers, veterinary care providers, and biodegradable packaging companies.

CPC Classifications

Section	Class	Group
A	A61	A61K39/09
A	A61	A61K35/744
A	A61	A61K2039/585
A	A61	A61P37/04

Section 103 Obviousness Analysis (PHOSITA)

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Field of Art

Biotechnology and immunomodulatory compositions, specifically focusing on bacterial flagellin polypeptides and their applications in pharmaceutical, agricultural, and industrial contexts. Requires expertise in microbiology, immunology, protein engineering, and interdisciplinary applications of bacterial proteins

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in microbiology or biotechnology, familiar with protein characterization, immunological responses, and cross-disciplinary applications of bacterial proteins. Possesses knowledge of protein structure-function relationships and ability to explore novel applications of known molecular components

Obviousness Rationale

A PHOSITA would recognize the inherent immunomodulatory properties of Enterococcus gallinarum flagellin polypeptides disclosed in the source patent and find it predictable to extend these properties across diverse applications. The fundamental immunostimulatory mechanism of flagellin polypeptides suggests transferable utility in multiple domains, making the PTD's proposed variations a logical extension of the original patent's teachings. The technical understanding of how flagellin proteins interact with immune systems provides a clear pathway for exploring alternative implementation contexts.

Obvious Combinations & Variations

Source Patent Element

Pharmaceutical composition with Enterococcus flagellin polypeptide for immune response stimulation

PTD Variation

Agricultural application to stimulate plant defense responses

Obviousness Reasoning

Known immunomodulatory mechanisms of flagellin are predictably transferable between biological systems, representing a straightforward extrapolation of existing scientific understanding

Source Patent Element

Isolated flagellin polypeptide with sequence identity to SEQ ID NO: 1

PTD Variation

Bioremediation application to enhance microbial degradation processes

Obviousness Reasoning

Protein's structural characteristics suggest potential for interaction with microbial systems, making such application a predictable design choice for a skilled researcher

Source Patent Element

Enterococcus gallinarum strain with immunostimulatory properties

PTD Variation

Veterinary and cosmetic compositions leveraging immune response mechanisms

Obviousness Reasoning

Fundamental protein characteristics remain consistent across different implementation contexts, representing a logical extension of known immunological principles

Source Patent Element

Pharmaceutical formulation demonstrating immune system interaction

PTD Variation

Biodegradable packaging with microbial growth inhibition properties

Obviousness Reasoning

Antimicrobial characteristics of flagellin proteins provide a predictable basis for exploring alternative material science applications

35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. § 103, the variations disclosed in the Published Technical Disclosure (PTD) would have been obvious to a Person Having Ordinary Skill In The Art at the time of invention, given the teachings of US Patent 11857614. The PTD demonstrates that the fundamental immunomodulatory properties of Enterococcus gallinarum flagellin polypeptides provide a predictable framework for exploring diverse applications across agricultural, industrial, and biological domains, thereby rendering subsequent claims involving such variations unpatentable as obvious extensions of the prior art.

Original Patent Information

Patent Number	US 11,857,614
Title	Enterococcus gallinarum flagellin polypeptides
Assignee(s)	CJ BIOSCIENCE, INC.