Synergistic Integration of Enterococcus Gallinarum Flagellin Polypeptides with Emerging Technologies

Publication ID: 24-11857614_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Integration of Enterococcus Gallinarum Flagellin Polypeptides with Emerging Technologies,” Published Technical Disclosure No. 24-11857614_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857614_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,614.

Summary of the Inventive Concept

This inventive concept combines the Enterococcus gallinarum flagellin polypeptides from the original patent with cutting-edge technologies like AI, IoT, blockchain, and novel biomaterials to create a new, more powerful system for disease treatment and health management.

Background and Problem Solved

The original patent disclosed pharmaceutical compositions comprising Enterococcus gallinarum flagellin polypeptides for treating diseases. However, these compositions had limitations in terms of real-time health monitoring, secure data management, and personalized treatment. The new inventive concept addresses these limitations by integrating the flagellin polypeptides with emerging technologies to create a more comprehensive and effective system.

Detailed Description of the Inventive Concept

The inventive concept consists of synergistic combinations of the Enterococcus gallinarum flagellin polypeptides with various emerging technologies. For instance, the polypeptides can be used in conjunction with AI-driven predictive analytics engines to optimize disease treatment outcomes. The polypeptides can also be integrated with wearable IoT devices for real-time health monitoring, enabling more effective disease management. Additionally, the polypeptides can be combined with novel biomaterials to enhance immune response and tissue regeneration. Furthermore, the inventive concept encompasses computer-implemented systems for personalized disease diagnosis and treatment using the flagellin polypeptides as biomarkers, as well as hybrid systems integrating the polypeptides with decentralized blockchain networks for secure and transparent health data management.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious because it combines the Enterococcus gallinarum flagellin polypeptides with distinct emerging technologies to create a more powerful and comprehensive system. The inventive concept's synergistic combinations and integrations of these technologies with the polypeptides provide a new and unexpected solution to the limitations of the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include integrating the flagellin polypeptides with other emerging technologies like robotics, nanotechnology, or 3D printing. Variations of the concept could also involve using different types of biomarkers or biomaterials in combination with the polypeptides.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the healthcare and biotechnology industries, particularly in the areas of disease treatment, health management, and personalized medicine. The market for this concept is expected to be substantial, driven by the growing need for more effective and efficient healthcare solutions.

CPC Classifications

SectionClassGroup
A A61 A61K39/09
A A61 A61K35/744
A A61 A61K2039/585
A A61 A61P37/04

Field of Art

Biotechnology and pharmaceutical sciences, specifically immunology, bacterial polypeptide engineering, and medical treatment technologies with a focus on flagellin-based immune response modulation

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in microbiology or biotechnology, familiar with protein engineering, immunological techniques, digital health technologies, and emerging biomedical integration strategies

Obviousness Rationale

A person of ordinary skill would recognize that integrating the Enterococcus gallinarum flagellin polypeptides with emerging digital and biotechnological platforms represents a predictable extension of the source patent's core immunological technology. The combination of known flagellin-based immune response techniques with established digital health technologies follows a logical progression of medical innovation. The PTD's variations demonstrate standard technological convergence strategies commonly employed in modern biomedical research.

Obvious Combinations & Variations

Source Patent Element
Enterococcus gallinarum flagellin polypeptide with immune response stimulation capabilities
PTD Variation
Integration with AI-driven predictive analytics for optimizing disease treatment outcomes
Obviousness Reasoning
Applying machine learning to biological data is a well-established technique, and using flagellin polypeptides as biomarkers represents a predictable application of known computational methods to immunological research
Source Patent Element
Pharmaceutical composition with flagellin polypeptide
PTD Variation
Combination with wearable IoT devices for real-time health monitoring
Obviousness Reasoning
Integrating biological markers with digital monitoring technologies is a standard approach in personalized medicine, representing an obvious technological convergence
Source Patent Element
Immune response stimulation using flagellin polypeptides
PTD Variation
Combination with novel biomaterials for enhanced tissue regeneration
Obviousness Reasoning
Exploring synergistic interactions between biological compounds and advanced materials is a routine research strategy in biotechnology with predictable investigative approaches
Source Patent Element
Isolated Enterococcus flagellin polypeptide with therapeutic potential
PTD Variation
Blockchain-based secure health data management system
Obviousness Reasoning
Applying distributed ledger technologies to medical data management represents a standard technological evolution with clear motivation and predictable implementation strategies
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed in this publication would have been obvious to a person having ordinary skill in the art at the time of invention, as they represent predictable combinations of the flagellin polypeptide technology disclosed in US Patent 11857614 with contemporaneous digital health and biotechnological platforms. The disclosed variations fail to demonstrate sufficient non-obvious characteristics to distinguish from the existing technological landscape in immunological and digital health research.

Original Patent Information

Patent NumberUS 11,857,614
TitleEnterococcus gallinarum flagellin polypeptides
Assignee(s)CJ BIOSCIENCE, INC.