Synergistic Peptide-based Vaccination Systems

Publication ID: 24-11857615_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Peptide-based Vaccination Systems,” Published Technical Disclosure No. 24-11857615_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857615_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,615.

Summary of the Inventive Concept

Integrating peptide-based vaccines with AI, IoT, blockchain, and nanomaterials to create powerful, personalized, and secure vaccination systems.

Background and Problem Solved

The original patent disclosed peptide-based vaccines for antimicrobial prophylaxis and therapy, but it had limitations in terms of personalization, data tracking, and security. The new inventive concept addresses these limitations by combining the peptide-based vaccines with cutting-edge technologies to create a more effective, efficient, and secure system.

Detailed Description of the Inventive Concept

The inventive concept integrates a peptide-based vaccine with an AI-powered analytics engine for tracking and predicting immune responses, a blockchain-based secure data storage module for storing vaccination records and tracking vaccine efficacy, and an IoT-enabled monitoring device for real-time monitoring of vaccine administration and efficacy. The system can be further personalized by optimizing peptide sequences using machine learning algorithms and tailoring vaccination schedules to an individual's genetic profile.

Novelty and Inventive Step

The new claims introduce a synergistic combination of peptide-based vaccines with AI, IoT, blockchain, and nanomaterials, which provides a non-obvious solution to the limitations of the original patent. The integration of these technologies enables a more effective, efficient, and secure vaccination system that is not anticipated by the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include using different AI algorithms for analytics, incorporating additional sensors or monitoring devices, or integrating with existing healthcare infrastructure. Variations could include using different peptide sequences, adjuvants, or delivery vehicles, or applying the system to different diseases or applications.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the vaccine and pharmaceutical industries, particularly in the areas of personalized medicine, infectious disease prevention, and antimicrobial resistance. The system's ability to provide secure, real-time tracking and monitoring of vaccine efficacy and administration could also have applications in public health and epidemiology.

CPC Classifications

SectionClassGroup
A A61 A61K39/104
C C07 C07K14/212
A A61 A61K2039/543
A A61 A61K2039/55505
A A61 A61K2039/55566
G G01 G01N2333/22
G G01 G01N2469/20

Field of Art

Biotechnology, immunology, and vaccine development, with expertise in peptide-based vaccine design, bioinformatics, and advanced medical technologies

Person of Ordinary Skill (PHOSITA) Profile

A skilled researcher with advanced degrees in biotechnology or molecular biology, familiar with vaccine development techniques, AI/machine learning applications in biological research, and emerging digital health technologies

Obviousness Rationale

A PHOSITA would recognize that integrating digital technologies with peptide-based vaccine development represents a natural progression of existing biotechnological approaches. The combination of AI, blockchain, and IoT with peptide vaccine design follows established patterns of technological convergence in medical research. The proposed variations represent predictable extensions of known techniques in vaccine development and digital health monitoring.

Obvious Combinations & Variations

Source Patent Element
Polypeptide-based pharmaceutical composition for vaccination against Acinetobacter baumannii
PTD Variation
AI-powered optimization of peptide sequences and personalized vaccination scheduling
Obviousness Reasoning
Applying machine learning to vaccine design is a known technique in biotechnology, representing a predictable application of computational methods to improve existing vaccine development processes
Source Patent Element
Pharmaceutical composition with specific peptide sequences and adjuvants
PTD Variation
Nanomaterial-based delivery vehicle and IoT-enabled monitoring device
Obviousness Reasoning
Exploring advanced drug delivery mechanisms and real-time monitoring is a standard approach in developing more effective vaccine technologies, representing an obvious improvement to existing vaccination methods
Source Patent Element
Polypeptide composition with sequence identity variations
PTD Variation
Blockchain-based secure data storage and genomics-based diagnostic integration
Obviousness Reasoning
Combining digital security technologies with medical research is a predictable solution for addressing data management and tracking challenges in vaccine development
Source Patent Element
Vaccination composition with specific amino acid sequences
PTD Variation
High-throughput screening of peptide libraries using machine learning
Obviousness Reasoning
Applying computational methods to accelerate peptide library screening is a known technique in biotechnology, representing an obvious optimization of existing research methodologies
Source Patent Element
Peptide-based pharmaceutical composition
PTD Variation
Antimicrobial resistance prediction system using integrated technologies
Obviousness Reasoning
Developing predictive systems for emerging medical challenges is a standard approach in biotechnological research, representing a logical extension of existing vaccine development strategies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857615 and the published technical disclosure, a person having ordinary skill in the art would find the proposed variations obvious and predictable extensions of existing vaccine development technologies. The integration of AI, blockchain, IoT, and advanced computational methods with peptide-based vaccine design represents a natural progression of known techniques in biotechnological research, rendering potential patent claims obvious and anticipated by the prior art.

Original Patent Information

Patent NumberUS 11,857,615
TitlePeptides derived from Acinetobacter baumannii and their use in vaccination
Assignee(s)Evaxion Biotech A/S