Novel Applications of Combination Therapy for Infection Prevention and Control

Publication ID: 24-11857617_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Novel Applications of Combination Therapy for Infection Prevention and Control,” Published Technical Disclosure No. 24-11857617_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857617_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,617.

Summary of the Inventive Concept

This inventive concept leverages the core technology of the original patent to develop novel applications for preventing and controlling infections in various industries, including food safety, agriculture, medical devices, environmental pollution, and metal corrosion.

Background and Problem Solved

The original patent focused on treating and preventing infections in humans using a combination of antibiotic and vaccine therapy. However, this approach can be limited in its application to other fields. The new inventive concept addresses this limitation by exploring the use of combination therapy in entirely different industries, such as food safety, agriculture, and environmental pollution, where microbial growth and infection pose significant challenges.

Detailed Description of the Inventive Concept

The inventive concept involves the administration of a combination of antimicrobial agents and vaccines directed to specific causative agents of infection in various industries. For instance, in food safety, the combination therapy can be used to prevent microbial growth and spoilage in food products or packaging materials. In agriculture, the combination therapy can be used to reduce the risk of crop failure due to disease by administering a pesticide and vaccine to crops. Similarly, in medical devices, the combination therapy can be used to prevent biofilm formation on medical implants by applying a coating comprising antimicrobial agents and a vaccine. In environmental pollution, the combination therapy can be used to reduce the risk of oil spills by administering a bioremediation agent and vaccine to oil spill sites. Finally, in metal corrosion, the combination therapy can be used to prevent corrosion of metal surfaces by applying a coating comprising corrosion inhibitors and a vaccine.

Novelty and Inventive Step

The new inventive concept introduces a novel application of combination therapy beyond human infections, providing a non-obvious solution to the problem of microbial growth and infection in various industries. The inventive step lies in the recognition of the potential for combination therapy to be applied to different fields and the development of specific formulations and administration protocols tailored to each industry.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different types of antimicrobial agents, vaccines, and administration protocols tailored to specific industries. Additionally, the combination therapy could be used in conjunction with other technologies, such as nanotechnology or biotechnology, to enhance its effectiveness.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including food safety, agriculture, medical devices, environmental pollution, and metal corrosion. The market for combination therapy in these industries is substantial, with potential applications in food processing, agricultural production, medical device manufacturing, environmental remediation, and metal surface treatment.

CPC Classifications

SectionClassGroup
A A61 A61K39/12
A A61 A61K31/166
A A61 A61K45/06
A A61 A61P31/14
C C12 C12N7/00
A A61 A61K2039/545

Field of Art

Medical microbiology, pharmaceutical composition design, and interdisciplinary infection prevention technologies, encompassing medical treatment, agricultural protection, and industrial surface management

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degrees in microbiology, biotechnology, or pharmaceutical sciences, possessing expertise in combinatorial therapeutic approaches, vaccine design, and cross-industry antimicrobial strategies

Obviousness Rationale

The PTD represents a predictable extension of the source patent's core combination therapy concept by systematically applying the fundamental treatment methodology to diverse industrial contexts. A PHOSITA would recognize the inherent transferability of combination antimicrobial and vaccine strategies across different domains. The technical principles of targeted infection prevention remain consistent, merely requiring domain-specific adaptation of agents and administration protocols.

Obvious Combinations & Variations

Source Patent Element
Combination of anti-viral drugs and vaccines for treating coronavirus infections
PTD Variation
Applying combination therapy to food safety prevention of microbial spoilage
Obviousness Reasoning
Known technique of using antimicrobial agents with targeted vaccines, with predictable results of infection/contamination prevention across biological systems
Source Patent Element
Specific dosage and administration timing of therapeutic combinations
PTD Variation
Predetermined sequence administration of pesticide and crop disease vaccine
Obviousness Reasoning
Routine optimization of treatment protocol using established combinatorial therapeutic principles, representing standard design choice for skilled practitioners
Source Patent Element
Zinc-based and antibiotic formulations for infection management
PTD Variation
Corrosion inhibitor and microbial vaccine coatings for metal surface protection
Obviousness Reasoning
Extending protective coating technologies using known antimicrobial combination strategies, representing predictable technological translation
Source Patent Element
Method of administering live, inactivated, or attenuated causative agent vaccines
PTD Variation
Vaccine and bioremediation agent combination for environmental pollution mitigation
Obviousness Reasoning
Applying established vaccine integration principles to novel environmental remediation contexts, representing obvious technological adaptation
35 U.S.C. § 103 Summary: Based on US Patent 11857617's comprehensive combination therapy methodology, the present publication demonstrates that the extension of infection prevention strategies across diverse technological domains would be obvious to a person having ordinary skill in the art, rendering potential claims to such variations anticipated and non-patentable under standard obviousness analysis.

Original Patent Information

Patent NumberUS 11,857,617
TitleMethods for treating, ameliorating or preventing infections using drug and vaccination combination treatment
Assignee(s)TOPELIA AUST LIMITED (652 771 670)