Intelligent Vaccine Enhancement System (IVES)

Publication ID: 24-11857618_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Intelligent Vaccine Enhancement System (IVES),” Published Technical Disclosure No. 24-11857618_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857618_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,618.

Summary of the Inventive Concept

IVES integrates AI, IoT, blockchain, and nanomaterials to create a personalized vaccine administration system, enhancing immunogenicity and improving vaccine efficacy in elderly and immune-suppressed populations.

Background and Problem Solved

The original patent addresses the issue of poor vaccine efficacy in elderly and immune-suppressed populations by using saponins and agonists of the intracellular stimulator of interferon genes pathway. However, it lacks the ability to monitor and predict immune responses, secure vaccination records, and provide personalized insights. IVES solves these limitations by incorporating AI-powered analytics, IoT sensors, blockchain-based data storage, and nanomaterial-based adjuvants to create a more effective and efficient vaccine administration system.

Detailed Description of the Inventive Concept

IVES consists of four primary components: 1) a vaccine administration module, 2) an AI-powered analytics module, 3) an IoT sensor module, and 4) a blockchain-based data storage module. The AI-powered analytics module processes data from the IoT sensors, genomic data, and medical history to generate personalized insights and recommendations for enhancing immune responses. The blockchain-based data storage module securely stores vaccination records, AI-generated insights, and genomic data. The nanomaterial-based adjuvants are designed to target specific immune cells, enhancing the immune response. IVES can be used for various vaccine types, including influenza, and can be integrated into existing healthcare systems.

Novelty and Inventive Step

The new claims introduce the integration of AI, IoT, blockchain, and nanomaterials to create a personalized vaccine administration system, which is not present in the original patent. The inventive step lies in the synergistic combination of these technologies to enhance immunogenicity and improve vaccine efficacy.

Alternative Embodiments and Variations

IVES can be implemented in various ways, such as using different AI algorithms, IoT sensor configurations, or blockchain platforms. Additionally, IVES can be adapted for use in different populations, such as pediatric or immune-competent individuals, or for various vaccine types, including cancer or infectious disease vaccines.

Potential Commercial Applications and Market

IVES has significant commercial potential in the vaccine industry, particularly in the elderly and immune-suppressed populations. The system can be marketed to healthcare providers, pharmaceutical companies, and government agencies, offering a more effective and efficient vaccine administration system. The market potential is substantial, with the global vaccine market projected to reach $64 billion by 2027.

CPC Classifications

SectionClassGroup
A A61 A61K39/145
A A61 A61K39/39
A A61 A61P31/16
A A61 A61K2039/55
A A61 A61K2039/55555
A A61 A61K2039/55561
A A61 A61K2039/55577

Field of Art

Vaccine immunology, biotechnology, and medical informatics with a focus on geriatric and immunocompromised patient populations, involving immunological enhancement techniques and personalized medical technologies

Person of Ordinary Skill (PHOSITA) Profile

A multidisciplinary professional with expertise in immunology, data science, biotechnology, and medical informatics, possessing advanced degrees and experience in vaccine development, AI-driven medical technologies, and personalized medicine approaches

Obviousness Rationale

A PHOSITA would recognize that the integration of AI, IoT, and blockchain technologies into vaccine administration represents a predictable extension of existing personalized medicine approaches, particularly for enhancing vaccine efficacy in elderly populations. The disclosed system combines known technologies in a manner that would be obvious to a skilled practitioner seeking to improve vaccine response monitoring and personalization. The technical variations represent incremental improvements that leverage existing technological capabilities to address known challenges in vaccine immunogenicity.

Obvious Combinations & Variations

Source Patent Element
Influenza vaccine method for subjects over 65 years old using Quillaja saponins
PTD Variation
Adding AI-powered analytics and IoT sensor monitoring to track and predict immune response
Obviousness Reasoning
Predictable application of modern monitoring technologies to existing vaccine administration methods, representing a known technique for improving medical interventions
Source Patent Element
Vaccine adjuvant system using saponins
PTD Variation
Incorporating nanomaterial-based adjuvants designed to target specific immune cells
Obviousness Reasoning
Obvious extension of existing adjuvant technologies, utilizing known principles of targeted drug delivery and immune system modulation
Source Patent Element
Vaccine method for elderly populations
PTD Variation
Blockchain-based personalized vaccine development using genomic data analysis
Obviousness Reasoning
Predictable application of data science and personalized medicine approaches to existing vaccine development methodologies
Source Patent Element
Immunogenicity enhancement for influenza vaccines
PTD Variation
Machine learning algorithms for predicting immune response based on patient-specific factors
Obviousness Reasoning
Known technique of applying predictive analytics to medical interventions, representing a logical progression of personalized medicine technologies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857618 and the disclosed technical variations, a person having ordinary skill in the art would find the claimed innovations obvious and lacking inventive step. The combination of known technologies in vaccine administration, AI-driven analytics, and personalized medicine represents a predictable application of existing techniques to address known challenges in vaccine immunogenicity, thereby rendering the claimed innovations obvious to a skilled practitioner in the field.

Original Patent Information

Patent NumberUS 11,857,618
TitleBoosting immunogenicity of vaccines using saponins and agonists of the intracellular stimulator of interferon genes pathway
Assignee(s)Emory University