Multimodal Chromatography for Diverse Industrial Applications

The inventive concept extends the core technology of multimodal chromatography to new industries and use cases, enabling purification, separation, and detection of various biomolecules, microorganisms, and pollutants in agricultural, environmental, biomedical, and energy sectors.

The original patent disclosed a multimodal chromatography method for purifying HIV-1 envelope glycoprotein, demonstrating the effectiveness of this technology in biopharmaceutical applications. However, the original patent's limitations lie in its narrow focus on a specific biological molecule. This inventive concept addresses the problem of limited applicability by expanding the technology to tackle diverse industrial challenges, such as improving crop yields, treating wastewater, diagnosing diseases, producing biofuels, and removing heavy metals from soil.

The inventive concept involves the design and implementation of multimodal chromatography systems tailored to specific industrial applications. For instance, in agriculture, the system can separate and purify plant growth-promoting microorganisms to enhance crop yields. In environmental applications, the system can selectively capture and remove pollutants and contaminants from wastewater. In biomedical applications, the system can detect biomarkers in biological samples for disease diagnosis. In energy applications, the system can separate and purify biofuel-producing microorganisms. The multimodal chromatography system's versatility lies in its ability to adapt to different molecule types, sizes, and properties, making it a powerful tool for various industries.

The novelty of this inventive concept lies in its application of multimodal chromatography to entirely new industries and use cases, departing from the original patent's focus on HIV-1 envelope glycoprotein. The inventive step is the recognition of the technology's broad applicability and the development of tailored solutions for diverse industrial challenges.

Alternative embodiments of the inventive concept could include modifications to the multimodal resin, column design, and operating conditions to optimize performance for specific industrial applications. Variations could also involve integrating the multimodal chromatography system with other technologies, such as sensors, microfluidics, or machine learning algorithms, to enhance its capabilities and versatility.

The inventive concept has significant commercial potential across various industries, including agriculture, environmental remediation, biomedical diagnostics, and energy production. The target market includes companies, research institutions, and government agencies seeking innovative solutions to address pressing industrial challenges and improve their products, processes, and services.