AI-Integrated pDNA Vaccines for Personalized COVID-19 Protection

Publication ID: 24-11857621_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “AI-Integrated pDNA Vaccines for Personalized COVID-19 Protection,” Published Technical Disclosure No. 24-11857621_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857621_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,621.

Summary of the Inventive Concept

A novel system integrating AI, IoT, blockchain, and pDNA vaccines to provide personalized, adaptive, and secure COVID-19 protection

Background and Problem Solved

The original patent disclosed a pDNA vaccine against COVID-19, but it lacked the capability to provide personalized and adaptive protection. The new inventive concept addresses this limitation by combining the pDNA vaccine with AI-powered genomics analysis, IoT-enabled sensors, and blockchain-based patient data management, enabling real-time tracking and adaptation to emerging variants

Detailed Description of the Inventive Concept

The system consists of a pDNA vaccine, an AI-powered genomics analysis module that analyzes genomic data to identify personalized vaccine targets, an IoT-enabled sensor network that tracks vaccine efficacy and environmental factors, and a blockchain-based patient data management system that securely stores and shares patient data. The AI-driven protein design module engineers novel S protein variants for enhanced vaccine efficacy. The nanoparticle delivery system ensures targeted and efficient vaccine delivery. The blockchain-based platform enables secure sharing of SARS-CoV-2 genomic data and AI-powered predictive analytics for vaccine development

Novelty and Inventive Step

The new claims introduce the integration of AI, IoT, and blockchain technologies with pDNA vaccines, providing a novel and non-obvious solution for personalized and adaptive COVID-19 protection

Alternative Embodiments and Variations

Alternative embodiments may include the use of different AI algorithms, IoT sensor configurations, or blockchain platforms. Variations may include the integration of additional technologies, such as CRISPR gene editing or advanced materials, to further enhance vaccine efficacy and security

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the vaccine development and personalized medicine industries, with potential applications in pandemic preparedness, public health, and biodefense

CPC Classifications

SectionClassGroup
A A61 A61K39/215
A A61 A61K9/0019
A A61 A61P31/14
C C07 C07K14/005
A A61 A61K2039/53
A A61 A61K2039/54
A A61 A61K2039/545
C C12 C12N2770/20022
C C12 C12N2770/20034
C C12 C12N2770/20071

Original Patent Information

Patent NumberUS 11,857,621
TitleSynthetic pDNA vaccines against COVID-19
Assignee(s)Imam Abdulrahman Bin Faisal University