Published Technical Disclosure Archive

OPCML Fragment-based Environmental Monitoring and Diagnostic Systems

Publication ID: 24-11857624_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “OPCML Fragment-based Environmental Monitoring and Diagnostic Systems,” Published Technical Disclosure No. 24-11857624_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857624_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,624.

Summary of the Inventive Concept

The present inventive concept leverages the core technology of OPCML fragments to develop novel systems and methods for monitoring water quality, detecting agricultural pests, diagnosing neurological disorders, monitoring food spoilage, and detecting environmental toxins.

Background and Problem Solved

The original patent disclosed the use of OPCML fragments in cancer therapy, but it did not explore their potential in other fields. This inventive concept addresses the need for innovative solutions in environmental monitoring and diagnostics, where traditional methods are often inadequate or ineffective.

Detailed Description of the Inventive Concept

The newly generated claims describe various systems and methods that utilize OPCML fragments as biomarkers or sensors to detect specific environmental pollutants, pests, neurological disorders, food spoilage, or toxins. For instance, claim 1 describes a system for monitoring water quality by detecting OPCML fragments indicative of pollution. Claim 2 outlines a method for detecting agricultural pests using OPCML fragments as biomarkers. Similarly, claims 3-5 describe devices and systems for diagnosing neurological disorders, monitoring food spoilage, and detecting environmental toxins.

Novelty and Inventive Step

The new claims introduce a fundamentally new application of OPCML fragments, transitioning from cancer therapy to environmental monitoring and diagnostics. This shift in focus and technology constitutes a significant inventive step, as it requires a deep understanding of the OPCML fragment's properties and their potential uses in diverse fields.

Alternative Embodiments and Variations

Other potential implementations of the inventive concept could include using OPCML fragments in wearable devices for personal health monitoring, developing point-of-care diagnostic tools for remote or resource-constrained areas, or integrating OPCML fragments with machine learning algorithms for enhanced predictive capabilities.

Potential Commercial Applications and Market

The OPCML fragment-based environmental monitoring and diagnostic systems have vast commercial potential, targeting industries such as environmental consulting, agricultural technology, healthcare, and food safety. The market for these systems is substantial, driven by growing concerns about environmental sustainability, public health, and food security.

CPC Classifications

SectionClassGroup
A A61 A61K39/39558
A A61 A61K31/404
A A61 A61K31/506
A A61 A61K31/517
A A61 A61K31/555
A A61 A61K31/7064
A A61 A61K38/1774
A A61 A61K45/06
C C07 C07K16/28
C C07 C07K16/2863
C C07 C07K16/32
C C12 C12Q1/6886
C C12 C12Q2600/118
C C12 C12Q2600/156
C C12 C12Q2600/158

Field of Art

Biotechnology and molecular diagnostics, with expertise in protein fragment applications, biomarker detection, and interdisciplinary biomedical engineering

Person of Ordinary Skill (PHOSITA) Profile

A skilled professional with advanced degrees in biotechnology, molecular biology, or bioengineering, possessing comprehensive knowledge of protein fragment manipulation, diagnostic sensor technologies, and cross-domain biomedical applications

Obviousness Rationale

A PHOSITA would recognize that OPCML fragments possess inherent versatile properties that extend beyond cancer therapeutics, making their application to environmental monitoring and diagnostic systems a predictable and logical extension of the source patent's fundamental protein fragment technology. The core technical insight of using specific protein fragment characteristics for detection and identification can be readily translated across multiple domains by applying standard biotechnological techniques. The source patent's detailed characterization of OPCML fragments provides sufficient structural and functional information to enable a skilled practitioner to explore alternative diagnostic and sensing applications.

Obvious Combinations & Variations

Source Patent Element
OPCML fragment with specific residue ranges (39-219 and 39-310)
PTD Variation
Using identical OPCML fragment ranges as biomarkers for water quality, agricultural pest detection, and environmental toxin sensing
Obviousness Reasoning
The structural properties that make these fragments effective in cancer detection would predictably enable detection mechanisms in other biological systems, representing a known technique of repurposing molecular diagnostic tools
Source Patent Element
Fusion of OPCML fragment with non-OPCML polypeptide
PTD Variation
Creating sensor-compatible OPCML fragment configurations for microarray and diagnostic device integration
Obviousness Reasoning
Modifying protein fragments for enhanced detection is a standard biotechnological approach, representing a finite set of predictable engineering modifications
Source Patent Element
Cancer-specific tumor detection method
PTD Variation
Adapting the detection methodology to identify neurological disorders and food spoilage indicators
Obviousness Reasoning
Translating protein fragment detection principles across biological domains represents a routine application of molecular diagnostic techniques
Source Patent Element
Therapeutic protein fragment with specific molecular characteristics
PTD Variation
Utilizing identical molecular characteristics for environmental monitoring and diagnostic sensing
Obviousness Reasoning
Repurposing protein fragment detection mechanisms is a predictable extension when fundamental molecular interaction principles remain consistent
Source Patent Element
Method of identifying specific biological conditions using protein fragments
PTD Variation
Expanding fragment identification techniques to diverse environmental and diagnostic contexts
Obviousness Reasoning
Applying established protein fragment detection principles to new domains represents a standard scientific approach with predictable technological progression
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857624, a Person Having Ordinary Skill In The Art would find the disclosed environmental monitoring and diagnostic systems utilizing OPCML fragments to be obvious variations of the source patent's fundamental protein fragment technology. The systematic translation of molecular detection principles across biological domains represents a predictable technological extension that would be readily conceived by a skilled practitioner without requiring undue experimentation or non-obvious innovation.

Original Patent Information

Patent NumberUS 11,857,624
TitleCancer therapeutic methods utilizing OPCML fragment
Assignee(s)PAPYRUS THERAPEUTICS, INC.