Synergistic Cancer Therapeutic Systems

Publication ID: 24-11857624_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Cancer Therapeutic Systems,” Published Technical Disclosure No. 24-11857624_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857624_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,624.

Summary of the Inventive Concept

The present invention integrates OPCML-based cancer therapy with distinct technologies such as AI, IoT, blockchain, and nanomaterials to create a more powerful system for personalized cancer treatment, research, and data management.

Background and Problem Solved

Cancer is a leading cause of mortality worldwide, and current treatment options often have limited efficacy and significant side effects. The original patent disclosed the use of OPCML fragments for cancer therapy, but it lacked the scalability, precision, and security offered by modern technologies. The new inventive concept addresses these limitations by combining OPCML fragments with AI-driven recommendation engines, IoT-enabled wearable devices, blockchain-based data management platforms, and nanomaterial-based delivery vehicles.

Detailed Description of the Inventive Concept

The synergistic system comprises a database of OPCML fragments, which can be fused to non-OPCML polypeptides for enhanced efficacy. The AI-driven recommendation engine selects optimal treatment regimens based on patient-specific genomic data and OPCML fragment efficacy. IoT-enabled wearable devices enable real-time monitoring of treatment response and patient health, while the blockchain-based data management platform ensures secure and transparent sharing of research data and clinical trial results. The nanomaterial-based delivery vehicle facilitates targeted and controlled release of the OPCML fragment in cancer cells. This integrated system enables personalized cancer treatment, improves treatment outcomes, and accelerates research and development.

Novelty and Inventive Step

The new claims introduce the concept of integrating OPCML-based cancer therapy with distinct technologies, which is novel and non-obvious compared to the original patent. The use of AI, IoT, blockchain, and nanomaterials in conjunction with OPCML fragments provides a synergistic effect that enhances the efficacy, precision, and security of cancer treatment and research.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different AI algorithms, IoT devices, or blockchain platforms. Variations may involve the integration of OPCML fragments with other emerging technologies, such as CRISPR gene editing or synthetic biology.

Potential Commercial Applications and Market

The synergistic cancer therapeutic system has significant commercial potential in the pharmaceutical, biotechnology, and healthcare industries. It can be used for personalized cancer treatment, research, and data management, and has the potential to improve treatment outcomes, reduce healthcare costs, and accelerate the development of new cancer therapies.

CPC Classifications

SectionClassGroup
A A61 A61K39/39558
A A61 A61K31/404
A A61 A61K31/506
A A61 A61K31/517
A A61 A61K31/555
A A61 A61K31/7064
A A61 A61K38/1774
A A61 A61K45/06
C C07 C07K16/28
C C07 C07K16/2863
C C07 C07K16/32
C C12 C12Q1/6886
C C12 C12Q2600/118
C C12 C12Q2600/156
C C12 C12Q2600/158

Field of Art

Oncology, biotechnology, and medical therapeutics with a focus on targeted protein therapies and personalized medicine technologies. Requires advanced degrees in molecular biology, biochemistry, or biomedical engineering with expertise in cancer research, protein engineering, and computational healthcare technologies

Person of Ordinary Skill (PHOSITA) Profile

A skilled researcher with advanced training in molecular oncology, capable of understanding protein fragment modifications, computational healthcare technologies, and interdisciplinary medical treatment approaches. Familiar with emerging technologies in precision medicine and biotechnological innovation

Obviousness Rationale

A PHOSITA would recognize that integrating computational technologies with existing OPCML cancer therapeutic approaches represents a natural progression of personalized medicine. The combination of AI, IoT, blockchain, and nanomaterial delivery with established protein fragment therapies follows predictable technological convergence patterns in modern medical research. The technical elements disclosed demonstrate incremental improvements that would be apparent to a skilled practitioner seeking to enhance cancer treatment efficacy and data management.

Obvious Combinations & Variations

Source Patent Element
OPCML protein fragment therapy targeting cancer cells
PTD Variation
AI-driven recommendation engine for selecting optimal OPCML fragment treatments
Obviousness Reasoning
Predictable application of machine learning to personalized medicine, representing a known technique for optimizing therapeutic selection based on genomic data
Source Patent Element
OPCML fragment fusion with non-OPCML polypeptides
PTD Variation
Nanomaterial-based delivery vehicle for targeted OPCML fragment release
Obviousness Reasoning
Logical extension of protein engineering principles, utilizing known targeted delivery mechanisms to improve therapeutic precision
Source Patent Element
Cancer treatment method using protein fragments
PTD Variation
Blockchain-based platform for secure research data and clinical trial management
Obviousness Reasoning
Standard technological approach to improving research transparency and data integrity in medical research, representing a finite and predictable solution to existing data management challenges
Source Patent Element
HER2-positive and HER2-negative cancer tumor treatments
PTD Variation
IoT-enabled wearable devices for real-time treatment response monitoring
Obviousness Reasoning
Obvious implementation of continuous patient monitoring technologies in precision oncology, following established trends in digital health monitoring
Source Patent Element
OPCML protein fragment cancer therapy
PTD Variation
Computer-implemented system for predicting cancer prognosis using machine learning
Obviousness Reasoning
Predictable application of computational techniques to existing medical diagnostic approaches, representing a known method of enhancing prognostic capabilities
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed herein would have been obvious to a person having ordinary skill in the art at the time of invention, as they represent predictable combinations of known technologies with the foundational teachings of US Patent 11857624. The incremental technological integrations demonstrate no inventive leap beyond the ordinary capabilities of skilled practitioners in oncological research and personalized medicine technologies.

Original Patent Information

Patent NumberUS 11,857,624
TitleCancer therapeutic methods utilizing OPCML fragment
Assignee(s)PAPYRUS THERAPEUTICS, INC.