AI-Driven Oxygen Therapeutic Systems for Enhanced Glioblastoma Treatment

Publication ID: 24-11857627_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “AI-Driven Oxygen Therapeutic Systems for Enhanced Glioblastoma Treatment,” Published Technical Disclosure No. 24-11857627_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857627_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,627.

Summary of the Inventive Concept

A novel, integrated system combining oxygen therapeutics with AI, IoT, blockchain, and machine learning to optimize glioblastoma treatment outcomes, enhance patient care, and improve data management.

Background and Problem Solved

The original patent disclosed the use of oxygen therapeutics in combination with repeated administrations of chemotherapy medications and/or radiation therapy. However, it did not address the limitations of treatment scheduling, patient data management, and personalized treatment planning. The new inventive concept addresses these limitations by integrating oxygen therapeutics with advanced technologies to create a more effective and efficient treatment system.

Detailed Description of the Inventive Concept

The AI-driven oxygen therapeutic system comprises a radiotherapy module, a chemotherapy module, and an oxygen therapeutic module, which are integrated with an AI-powered predictive analytics module, a blockchain-based data management system, and a wearable IoT device. The system optimizes treatment schedules based on patient response data, securely stores and tracks patient treatment data and outcomes, and enables real-time monitoring of patient vital signs and treatment response. The oxygen therapeutic module administers a water emulsion of perfluoropentane, which enhances the effectiveness of radiotherapy and chemotherapy. The system also utilizes machine learning algorithms to analyze patient medical imaging data and identify optimal treatment strategies.

Novelty and Inventive Step

The new claims introduce the integration of oxygen therapeutics with AI, IoT, blockchain, and machine learning technologies, which is not obvious from the original patent. The inventive concept's novelty lies in the synergistic combination of these technologies to create a more powerful and effective treatment system.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different oxygen therapeutic agents, varying the dosage and administration schedule of the oxygen therapeutic, or incorporating additional advanced technologies such as robotics or virtual reality. Variations could also include the development of specific systems for different types of cancer or medical conditions.

Potential Commercial Applications and Market

The AI-driven oxygen therapeutic system has significant commercial potential in the healthcare industry, particularly in the fields of oncology and radiation therapy. The system could be marketed to hospitals, cancer centers, and research institutions, and could also be used in clinical trials and research studies.

CPC Classifications

SectionClassGroup
A A61 A61K41/0038
A A61 A61K9/0019
A A61 A61K9/107
A A61 A61K31/02
A A61 A61K33/00
A A61 A61K39/395
A A61 A61K45/06
A A61 A61K47/10
A A61 A61K47/24
A A61 A61K47/26
A A61 A61N5/10
A A61 A61K2039/505
A A61 A61K2039/545
A A61 A61N2005/1098

Field of Art

Medical oncology, radiotherapy, and therapeutic drug delivery systems, with specialized expertise in cancer treatment technologies, particularly glioblastoma interventions and oxygen therapeutic applications

Person of Ordinary Skill (PHOSITA) Profile

A medical professional with advanced training in oncology, having expertise in radiation therapy, chemotherapy protocols, pharmaceutical formulations, and emerging medical technologies, with knowledge of computational methods in treatment optimization

Obviousness Rationale

A person having ordinary skill would recognize that integrating computational technologies with established medical treatment protocols represents a natural progression of medical innovation. The source patent's core method of oxygen therapeutic administration provides a clear technical foundation for exploring advanced technological augmentations. The PTD's proposed AI, IoT, and machine learning integrations represent predictable extensions of existing medical informatics approaches to personalized treatment strategies.

Obvious Combinations & Variations

Source Patent Element
Perfluoropentane water emulsion for enhancing radiotherapy effectiveness
PTD Variation
Adding AI-powered predictive analytics to optimize treatment scheduling based on patient response data
Obviousness Reasoning
Computational optimization of medical treatments is a known technique, and applying machine learning to personalize therapeutic protocols represents a predictable application of existing technological capabilities
Source Patent Element
Multi-fraction radiotherapy method for glioblastoma treatment
PTD Variation
Incorporating blockchain technology for secure patient data tracking and management
Obviousness Reasoning
Secure medical data management is a recognized challenge in healthcare, and blockchain represents a foreseeable technological solution for addressing data integrity and patient privacy concerns
Source Patent Element
Intravenous administration of oxygen therapeutic agents
PTD Variation
Integrating wearable IoT devices for real-time patient vital sign and treatment response monitoring
Obviousness Reasoning
Remote patient monitoring is an established medical technology trend, and connecting treatment protocols with continuous physiological tracking represents an obvious technological progression
Source Patent Element
Chemotherapy and radiotherapy treatment protocols
PTD Variation
Implementing machine learning algorithms to analyze medical imaging and identify optimal treatment strategies
Obviousness Reasoning
Computational image analysis and treatment optimization are well-established approaches in medical imaging, representing a logical extension of existing diagnostic and therapeutic methodologies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857627 and the disclosed technological variations, a person having ordinary skill in the art would find the proposed AI-driven oxygen therapeutic systems for glioblastoma treatment to be obvious variations of existing medical treatment methodologies. The incremental technological augmentations represent predictable applications of known computational techniques to established medical protocols, thereby rendering potential patent claims obvious and anticipatable as prior art.

Original Patent Information

Patent NumberUS 11,857,627
TitleFractionated radiotherapy and chemotherapy with an oxygen therapeutic
Assignee(s)NuvOx Pharma LLC