Personalized Oxygen Therapy Systems for Cancer Treatment

Publication ID: 24-11857627_0010_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Personalized Oxygen Therapy Systems for Cancer Treatment,” Published Technical Disclosure No. 24-11857627_0010_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857627_0010_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,627.

Summary of the Inventive Concept

A next-generation oxygen therapeutic system that leverages machine learning, non-invasive imaging, and wearable devices to provide personalized oxygen therapy for cancer patients, enhancing treatment outcomes and improving patient care.

Background and Problem Solved

The original patent disclosed the use of oxygen therapeutics in combination with chemotherapy and radiation therapy. However, this approach had limitations, including the inability to provide customized oxygen doses and real-time tumor oxygenation feedback. The new inventive concept addresses these limitations by integrating machine learning, non-invasive imaging, and wearable devices to provide personalized oxygen therapy.

Detailed Description of the Inventive Concept

The inventive concept comprises a system for personalized oxygen therapy in cancer treatment, which includes a machine learning-based predictive model for determining optimal oxygen levels in individual patients. The system also features an oxygen therapeutic delivery system adapted to provide customized oxygen doses based on the predictive model. Additionally, the system may incorporate a non-invasive imaging system for real-time tumor oxygenation feedback and a wearable device for continuous oxygen monitoring and personalized oxygen therapy. The system may also integrate with immunotherapy agents and predictive models for determining optimal oxygen levels and immunotherapy dosing regimens.

Novelty and Inventive Step

The new claims introduce the use of machine learning, non-invasive imaging, and wearable devices to provide personalized oxygen therapy, which is a significant departure from the original patent's approach. The integration of these technologies enables real-time tumor oxygenation feedback, customized oxygen doses, and improved treatment outcomes, making the new inventive concept novel and non-obvious.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include the use of different machine learning algorithms, various types of non-invasive imaging systems, and different wearable device designs. Additionally, the system may be adapted for use in different types of cancer treatment, such as radiation therapy or chemotherapy.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the cancer treatment market, particularly in the areas of personalized medicine and precision oncology. The system's ability to provide customized oxygen therapy and improve treatment outcomes could lead to increased adoption and revenue growth in the market.

CPC Classifications

SectionClassGroup
A A61 A61K41/0038
A A61 A61K9/0019
A A61 A61K9/107
A A61 A61K31/02
A A61 A61K33/00
A A61 A61K39/395
A A61 A61K45/06
A A61 A61K47/10
A A61 A61K47/24
A A61 A61K47/26
A A61 A61N5/10
A A61 A61K2039/505
A A61 A61K2039/545
A A61 A61N2005/1098

Field of Art

Medical oncology, radiotherapy, and therapeutic delivery systems with a focus on oxygen therapeutics and cancer treatment technologies involving precision medicine, imaging, and personalized treatment approaches

Person of Ordinary Skill (PHOSITA) Profile

A medical professional or biomedical engineer with advanced training in oncology, medical device design, machine learning applications in healthcare, and expertise in developing adaptive therapeutic delivery systems

Obviousness Rationale

A PHOSITA would recognize that integrating machine learning, real-time imaging, and adaptive delivery systems with existing oxygen therapeutic approaches represents a predictable technological progression in personalized cancer treatment. The fundamental principles of oxygen enhancement during cancer therapy remain consistent, with the PTD merely introducing computational and monitoring technologies to optimize existing therapeutic strategies. The core therapeutic mechanism of oxygen delivery remains substantially unchanged from the source patent's teachings.

Obvious Combinations & Variations

Source Patent Element
Perfluoropentane emulsion for enhancing radiation therapy oxygenation
PTD Variation
Machine learning-based predictive model for customizing oxygen therapeutic dosing
Obviousness Reasoning
Predictable application of computational optimization to existing therapeutic protocols, representing a routine design enhancement for precision medicine approaches
Source Patent Element
Intravenous administration of oxygen therapeutic
PTD Variation
Wearable device for continuous oxygen monitoring and adaptive delivery
Obviousness Reasoning
Known trend in medical technology toward patient-centric, real-time monitoring systems with minimal invasiveness
Source Patent Element
Multi-fraction radiotherapy treatment method
PTD Variation
Non-invasive imaging integration for real-time tumor oxygenation feedback
Obviousness Reasoning
Logical extension of existing imaging technologies to provide more granular treatment monitoring and adjustment capabilities
Source Patent Element
Cancer treatment using oxygen therapeutics
PTD Variation
Integration with immunotherapy predictive dosing models
Obviousness Reasoning
Predictable combination of complementary medical technologies following established interdisciplinary research approaches
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857627 and the disclosed technological variations, a person of ordinary skill in the art would find the claimed personalized oxygen therapy system and methods obvious and anticipated, as the proposed innovations represent straightforward computational and monitoring enhancements to established oxygen therapeutic approaches in cancer treatment.

Original Patent Information

Patent NumberUS 11,857,627
TitleFractionated radiotherapy and chemotherapy with an oxygen therapeutic
Assignee(s)NuvOx Pharma LLC