Synergistic Integration of Shiga Toxin Effector Polypeptides with Emerging Technologies

Publication ID: 24-11857628_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Integration of Shiga Toxin Effector Polypeptides with Emerging Technologies,” Published Technical Disclosure No. 24-11857628_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857628_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,628.

Summary of the Inventive Concept

The inventive concept integrates Shiga toxin effector polypeptides with emerging technologies such as AI, IoT, blockchain, and new materials to create a new, more powerful system for site-specific conjugation, disease treatment, and personalized medicine.

Background and Problem Solved

The original patent disclosed cell-targeting molecules and/or components of cell-targeting molecules comprising site-specific amino acid residues for linking Shiga toxin effector polypeptides to binding regions. However, the original patent had limitations in terms of scalability, security, and precision. The new inventive concept addresses these limitations by integrating Shiga toxin effector polypeptides with emerging technologies to create a more efficient, secure, and precise system.

Detailed Description of the Inventive Concept

The new inventive concept comprises a blockchain-based secure data storage module for storing and managing polypeptide sequences, an AI-powered polypeptide design module for generating optimized polypeptide sequences, and a cell-targeting molecule generation module for generating cell-targeting molecules based on the optimized polypeptide sequences. The system can be integrated with IoT-enabled biosensors for real-time detection of extracellular target biomolecules. Additionally, the system can be used for personalized medicine by integrating the Shiga toxin effector polypeptide with an AI-powered diagnostic module and a blockchain-based secure data storage module.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious compared to the original patent because it integrates Shiga toxin effector polypeptides with emerging technologies, providing a new and unexpected solution to the problem of site-specific conjugation and disease treatment. The use of blockchain, AI, and IoT technologies provides a new level of security, precision, and scalability that is not achievable with the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different blockchain platforms, AI algorithms, or IoT devices. The system could also be integrated with other emerging technologies such as quantum computing or nanotechnology. Additionally, the system could be used for other applications such as vaccine development or gene therapy.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the fields of personalized medicine, disease treatment, and vaccine development. The system could be used by pharmaceutical companies, research institutions, and hospitals to develop new treatments and therapies. The market for the inventive concept is expected to grow significantly in the coming years as the demand for personalized medicine and precision healthcare increases.

CPC Classifications

SectionClassGroup
A A61 A61K45/06
A A61 A61K38/00
A A61 A61K38/164
A A61 A61K47/6829
C C07 C07K14/195
C C07 C07K14/25
A A61 A61K2039/6037
C C07 C07K2319/05
C C07 C07K2319/55

Original Patent Information

Patent NumberUS 11,857,628
TitleShiga toxin A subunit effector polypeptides, Shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
Assignee(s)Molecular Templates, Inc.