Adaptive Biosensors for Real-Time Environmental Monitoring
Legal Citation
Summary of the Inventive Concept
The invention applies Shiga toxin effector polypeptide technology to create novel biosensors and sensor arrays for monitoring environmental pollutants, agricultural crop health, and detecting infectious diseases in livestock, enabling real-time monitoring and predictive analytics.
Background and Problem Solved
The original patent disclosed cell-targeting molecules with site-specific conjugation capabilities. However, the existing technology is limited to medical applications. The new inventive concept addresses the need for real-time monitoring and detection of environmental pollutants, agricultural crop health, and infectious diseases in livestock, which are critical issues in today's world.
Detailed Description of the Inventive Concept
The inventive concept comprises Shiga toxin effector polypeptide-based sensors and sensor arrays that can detect specific biomolecules associated with environmental pollutants, fungal infections in crops, and infectious diseases in livestock. These sensors are integrated with wireless communication devices, machine learning algorithms, and cloud-based data analytics platforms to enable real-time monitoring and predictive analytics. The sensors can be adapted for use in point-of-care diagnostic devices, biosensors, and other applications.
Novelty and Inventive Step
The new claims introduce novel applications of Shiga toxin effector polypeptide technology in environmental monitoring, agricultural crop health, and infectious disease detection, which are not addressed in the original patent. The inventive step lies in the adaptation of the core technology to these new fields, enabling real-time monitoring and predictive analytics.
Alternative Embodiments and Variations
Alternative embodiments may include the use of different types of sensors, such as optical or electrochemical sensors, or the integration of the Shiga toxin effector polypeptide-based sensors with other technologies, such as IoT devices or artificial intelligence platforms. Variations may include the development of handheld devices or wearable sensors for real-time monitoring.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in the environmental monitoring, agricultural, and livestock industries, with applications in real-time monitoring, predictive analytics, and supply chain management. The market for environmental monitoring and agricultural technology is projected to grow significantly in the coming years, and the inventive concept is well-positioned to capture a share of this market.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K45/06 |
| A | A61 | A61K38/00 |
| A | A61 | A61K38/164 |
| A | A61 | A61K47/6829 |
| C | C07 | C07K14/195 |
| C | C07 | C07K14/25 |
| A | A61 | A61K2039/6037 |
| C | C07 | C07K2319/05 |
| C | C07 | C07K2319/55 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biotechnology and molecular engineering, focusing on protein engineering, biosensor development, and targeted molecular diagnostics, with expertise in protein modification, biomolecular interactions, and sensor design
Person of Ordinary Skill (PHOSITA) Profile
A skilled practitioner with advanced degrees in molecular biology or bioengineering, experienced in protein engineering techniques, familiar with Shiga toxin protein structures, capable of designing targeted molecular sensors and understanding protein modification strategies
Obviousness Rationale
A person skilled in the art would recognize the inherent adaptability of Shiga toxin effector polypeptides for diverse sensing applications based on their modular protein structure and site-specific modification capabilities. The source patent's detailed protein engineering approach provides a clear framework for extending the technology into environmental monitoring and diagnostic contexts. The PTD's variations represent predictable extensions of the core protein engineering principles established in the original patent, applying known molecular design techniques to create novel sensor platforms.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,628 |
|---|---|
| Title | Shiga toxin A subunit effector polypeptides, Shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation |
| Assignee(s) | Molecular Templates, Inc. |