Adaptive Biosensors for Real-Time Environmental Monitoring

Publication ID: 24-11857628_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Adaptive Biosensors for Real-Time Environmental Monitoring,” Published Technical Disclosure No. 24-11857628_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857628_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,628.

Summary of the Inventive Concept

The invention applies Shiga toxin effector polypeptide technology to create novel biosensors and sensor arrays for monitoring environmental pollutants, agricultural crop health, and detecting infectious diseases in livestock, enabling real-time monitoring and predictive analytics.

Background and Problem Solved

The original patent disclosed cell-targeting molecules with site-specific conjugation capabilities. However, the existing technology is limited to medical applications. The new inventive concept addresses the need for real-time monitoring and detection of environmental pollutants, agricultural crop health, and infectious diseases in livestock, which are critical issues in today's world.

Detailed Description of the Inventive Concept

The inventive concept comprises Shiga toxin effector polypeptide-based sensors and sensor arrays that can detect specific biomolecules associated with environmental pollutants, fungal infections in crops, and infectious diseases in livestock. These sensors are integrated with wireless communication devices, machine learning algorithms, and cloud-based data analytics platforms to enable real-time monitoring and predictive analytics. The sensors can be adapted for use in point-of-care diagnostic devices, biosensors, and other applications.

Novelty and Inventive Step

The new claims introduce novel applications of Shiga toxin effector polypeptide technology in environmental monitoring, agricultural crop health, and infectious disease detection, which are not addressed in the original patent. The inventive step lies in the adaptation of the core technology to these new fields, enabling real-time monitoring and predictive analytics.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different types of sensors, such as optical or electrochemical sensors, or the integration of the Shiga toxin effector polypeptide-based sensors with other technologies, such as IoT devices or artificial intelligence platforms. Variations may include the development of handheld devices or wearable sensors for real-time monitoring.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the environmental monitoring, agricultural, and livestock industries, with applications in real-time monitoring, predictive analytics, and supply chain management. The market for environmental monitoring and agricultural technology is projected to grow significantly in the coming years, and the inventive concept is well-positioned to capture a share of this market.

CPC Classifications

SectionClassGroup
A A61 A61K45/06
A A61 A61K38/00
A A61 A61K38/164
A A61 A61K47/6829
C C07 C07K14/195
C C07 C07K14/25
A A61 A61K2039/6037
C C07 C07K2319/05
C C07 C07K2319/55

Original Patent Information

Patent NumberUS 11,857,628
TitleShiga toxin A subunit effector polypeptides, Shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
Assignee(s)Molecular Templates, Inc.