Synergistic Abuse Deterrent Pharmaceutical Systems

Publication ID: 24-11857629_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Abuse Deterrent Pharmaceutical Systems,” Published Technical Disclosure No. 24-11857629_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857629_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,629.

Summary of the Inventive Concept

Integrating abuse deterrent pharmaceutical compositions with AI, IoT, blockchain, and nanomaterials to create a more powerful system for preventing drug abuse and ensuring personalized drug delivery.

Background and Problem Solved

The original patent disclosed abuse deterrent pharmaceutical compositions that addressed opioid abuse. However, these compositions had limitations in tracking and controlling dosage, as well as ensuring personalized delivery. The new inventive concept addresses these limitations by synergistically combining the abuse deterrent pharmaceutical composition with distinct technologies to create a more robust system.

Detailed Description of the Inventive Concept

The new inventive concept comprises a synergistic combination of an abuse deterrent pharmaceutical composition and one or more of the following: AI-powered dosage tracking devices, blockchain-secured, IoT-enabled pharmaceutical compositions, pH-dependent solubility features, nanomaterial-based delivery systems, pH-modifying features, microchip-enabled tracking devices, and AI-powered genomic analysis tools. These components work together to monitor and control the release of the pharmaceutically active ingredient, track and verify dosage, and predict user response to the pharmaceutically active ingredient.

Novelty and Inventive Step

The new claims introduce a synergistic combination of distinct technologies that provides a more robust system for preventing drug abuse and ensuring personalized drug delivery. The integration of these technologies with the abuse deterrent pharmaceutical composition is new and non-obvious compared to the original patent.

Alternative Embodiments and Variations

Alternative embodiments may include integrating the abuse deterrent pharmaceutical composition with other technologies, such as machine learning algorithms, wearable devices, or cloud-based data analytics platforms. Variations may include using different types of nanomaterials, pH-modifying features, or genomic analysis tools.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the pharmaceutical industry, particularly in the areas of opioid abuse prevention and personalized drug delivery. Target markets may include pharmaceutical companies, healthcare providers, and government agencies focused on addressing the opioid epidemic.

CPC Classifications

SectionClassGroup
A A61 A61K47/02
A A61 A61K9/2009
A A61 A61K9/2027
A A61 A61K9/2077
A A61 A61K31/5517
A A61 A61K47/32

Field of Art

Pharmaceutical Formulation and Drug Delivery Systems, with expertise in abuse-deterrent pharmaceutical compositions, drug release mechanisms, and advanced drug delivery technologies

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degrees in pharmaceutical sciences, chemical engineering, or related fields, possessing knowledge of drug formulation, controlled release technologies, and emerging pharmaceutical delivery methods

Obviousness Rationale

A PHOSITA would recognize that the PTD's integration of digital technologies with abuse-deterrent pharmaceutical compositions represents a predictable extension of existing abuse prevention strategies. The core principles of controlled drug release and abuse prevention from the source patent are directly augmented by emerging technologies like AI, IoT, and nanomaterials. These technological additions provide enhanced monitoring and control mechanisms that naturally build upon the foundational abuse-deterrent composition disclosed in the original patent.

Obvious Combinations & Variations

Source Patent Element
Abuse deterrent pharmaceutical composition with buffering ingredients to control drug release
PTD Variation
AI-powered dosage tracking device that monitors and controls pharmaceutical ingredient release
Obviousness Reasoning
A PHOSITA would find it obvious to integrate digital monitoring technologies with existing abuse-deterrent compositions as a predictable solution to enhance drug safety and compliance
Source Patent Element
Pharmaceutical composition with ingredients to suppress peak plasma concentration
PTD Variation
Nanomaterial-based delivery system with pH-dependent solubility features
Obviousness Reasoning
Modifying drug delivery mechanisms using nanomaterials represents a known technique for improving pharmaceutical composition performance, with predictable results in controlled release
Source Patent Element
Composition designed to prevent abuse of drugs with narrow therapeutic index
PTD Variation
Blockchain-secured, IoT-enabled pharmaceutical composition with tracking and verification capabilities
Obviousness Reasoning
Implementing digital tracking and verification technologies is an obvious extension of existing abuse prevention strategies, utilizing well-known technological solutions to enhance pharmaceutical safety
Source Patent Element
Pharmaceutical composition with buffering ingredients to control drug release
PTD Variation
Microchip-enabled tracking device integrated with smart pill technology
Obviousness Reasoning
Incorporating electronic monitoring into pharmaceutical compositions is a predictable technological advancement for improving drug administration and preventing misuse
Source Patent Element
Abuse deterrent composition for drugs susceptible to abuse
PTD Variation
AI-powered genomic analysis tool for personalized drug delivery and dosage prediction
Obviousness Reasoning
Utilizing genomic analysis and AI for personalized drug delivery represents an obvious technological progression in pharmaceutical personalization and abuse prevention
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857629 and the published technical disclosure, a person of ordinary skill in the art would find the claimed variations obvious, as they represent predictable combinations of known abuse-deterrent pharmaceutical composition principles with emerging digital monitoring and delivery technologies. The disclosed variations constitute prior art that would render obvious any patent claims seeking to combine pharmaceutical abuse prevention with digital tracking and personalization technologies.

Original Patent Information

Patent NumberUS 11,857,629
TitleMethods and compositions for self-regulated release of active pharmaceutical ingredient
Assignee(s)Acurx Pharmaceuticals, Inc.