pH-Regulated Release Technology for Diverse Industries

Publication ID: 24-11857629_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “pH-Regulated Release Technology for Diverse Industries,” Published Technical Disclosure No. 24-11857629_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857629_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,629.

Summary of the Inventive Concept

This inventive concept adapts the core technology of the original patent, which controls the release of active pharmaceutical ingredients, to various non-pharmaceutical industries, including agriculture, environmental monitoring, wastewater treatment, and food preservation.

Background and Problem Solved

The original patent addressed the issue of opioid abuse by developing a self-regulated release system for pharmaceutical compositions. However, this technology has broader applications beyond the pharmaceutical industry. The new inventive concept solves the problem of inefficient nutrient release in livestock feeding, suboptimal crop yields, ineffective environmental pollutant detection, inadequate wastewater treatment, and shortened food shelf life.

Detailed Description of the Inventive Concept

The inventive concept involves applying the pH-modifying and buffering principles to diverse industries. In agriculture, pH-modifying feed additives regulate nutrient release and absorption, preventing over-ingestion and adverse health effects in livestock. In environmental monitoring, pH-sensitive sensors and buffering agents detect and neutralize pollutants. In wastewater treatment, pH-modifying agents control contaminant release and absorption, enhancing treatment efficacy. In food preservation, pH-dependent solubility coatings extend shelf life by regulating release and absorption of preservatives.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious because it applies the original patent's pH-regulated release technology to entirely new industries and use cases, which were not previously considered. The inventive step lies in recognizing the broader applicability of the technology and adapting it to solve distinct problems in various fields.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include using different pH-modifying agents, adapting the technology for use in other industries such as cosmetics or biotechnology, or integrating the pH-regulated release system with other technologies, such as nanotechnology or biodegradable materials.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the agriculture, environmental monitoring, wastewater treatment, and food preservation industries, offering solutions to pressing problems and opportunities for companies to differentiate themselves and gain a competitive advantage.

CPC Classifications

SectionClassGroup
A A61 A61K47/02
A A61 A61K9/2009
A A61 A61K9/2027
A A61 A61K9/2077
A A61 A61K31/5517
A A61 A61K47/32

Field of Art

Pharmaceutical formulation and controlled release technologies, with expertise in drug delivery systems, pH-dependent solubility mechanisms, and compositional modifications for regulated ingredient release across multiple technical domains

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degree in pharmaceutical sciences, chemical engineering, or materials science, possessing knowledge of drug delivery mechanisms, buffer systems, and cross-industry application of controlled release technologies

Obviousness Rationale

A PHOSITA would recognize the fundamental principle of pH-dependent release mechanism disclosed in the source patent as broadly applicable beyond pharmaceutical contexts. The core technological concept of using buffering ingredients to modulate ingredient release is fundamentally transferable across different technical domains. The PTD's variations represent predictable extensions of the original patent's core technological principle by applying known controlled release strategies to alternative industrial applications.

Obvious Combinations & Variations

Source Patent Element
pH-dependent buffering mechanism for controlling pharmaceutical ingredient release
PTD Variation
Applying pH-modulated release to agricultural feed additives for nutrient regulation
Obviousness Reasoning
Known technique of using pH-sensitive systems to control release, with predictable results in controlling nutrient absorption across biological systems
Source Patent Element
Composition with acid-soluble ingredients and buffering agents
PTD Variation
Environmental monitoring systems using pH-sensitive sensors and buffering agents to detect and neutralize pollutants
Obviousness Reasoning
Predictable application of pH-responsive material science principles to sensing and remediation technologies
Source Patent Element
Suppressing peak plasma concentration through buffering
PTD Variation
Controlling contaminant release in wastewater treatment through pH-modifying agents
Obviousness Reasoning
Extending known principles of concentration modulation to environmental treatment processes using established chemical engineering techniques
Source Patent Element
Pharmaceutical composition with ingredients having controlled solubility
PTD Variation
pH-dependent solubility coatings for food preservation to extend shelf life
Obviousness Reasoning
Applying known controlled release mechanisms to food science using standard materials engineering approaches
35 U.S.C. § 103 Summary: Based on US Patent 11857629's disclosure of pH-dependent release mechanisms, the present publication demonstrates that a person having ordinary skill in the art would find the extended applications of controlled release technology across agriculture, environmental monitoring, wastewater treatment, and food preservation to be obvious variations of the fundamental technological principles, thereby rendering subsequent claims in these domains obvious and anticipating potential patent attempts.

Original Patent Information

Patent NumberUS 11,857,629
TitleMethods and compositions for self-regulated release of active pharmaceutical ingredient
Assignee(s)Acurx Pharmaceuticals, Inc.