Synergistic Formulations of SN-38 with Poly(amino acid) Block Polymers and Distinct Technologies

Publication ID: 24-11857630_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Formulations of SN-38 with Poly(amino acid) Block Polymers and Distinct Technologies,” Published Technical Disclosure No. 24-11857630_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857630_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,630.

Summary of the Inventive Concept

This inventive concept integrates SN-38 formulations with poly(amino acid) block polymers and distinct technologies such as AI, IoT, blockchain, and novel materials to create powerful systems for targeted cancer treatment, optimized delivery, secure tracking, and sustained release.

Background and Problem Solved

The original patent disclosed formulations of SN-38 with poly(amino acid) copolymers, but these formulations had limitations in terms of personalized treatment planning, real-time monitoring, and secure tracking. The new inventive concept addresses these limitations by integrating the original formulation with distinct technologies to create a more powerful system.

Detailed Description of the Inventive Concept

The inventive concept comprises a formulation of SN-38 with a poly(amino acid) block copolymer, which is integrated with an AI-powered diagnostic module for personalized treatment planning. The system also includes an IoT-enabled wearable device for real-time monitoring of treatment efficacy. Furthermore, a blockchain-based platform is used for secure and transparent tracking of SN-38 formulations, and a novel material composition is designed for implantable devices with sustained release and improved biocompatibility. Additionally, a synergistic combination of SN-38 with a poly(amino acid) block copolymer and a graphene-based nanocarrier is used for enhanced bioavailability and targeted delivery to cancer cells.

Novelty and Inventive Step

The new claims introduce a novel combination of SN-38 formulations with poly(amino acid) block polymers and distinct technologies, which is not obvious from the original patent. The integration of these technologies provides a new and non-obvious solution for targeted cancer treatment, optimized delivery, and secure tracking.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include integrating the SN-38 formulation with other AI-powered modules, such as predictive analytics or natural language processing. Other variations could include using different types of nanocarriers or incorporating additional sensors for real-time monitoring.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the pharmaceutical and biotechnology industries, particularly in the areas of targeted cancer treatment, personalized medicine, and secure drug tracking. The market for these applications is expected to grow significantly in the coming years, driven by the increasing demand for effective and efficient cancer treatments.

CPC Classifications

SectionClassGroup
A A61 A61K47/34
A A61 A61K9/08
A A61 A61K9/19
A A61 A61K31/4375
A A61 A61K31/513
A A61 A61K31/519
A A61 A61K45/06
A A61 A61K47/26

Original Patent Information

Patent NumberUS 11,857,630
TitleFormulations of SN-38 with poly(amino acid) block polymers
Assignee(s)TYNDALL FORMULATION SERVICES, LLC