Enhanced Protection and Delivery of Multiple Therapeutic Proteins

An improved system for delivering multiple therapeutic proteins, including FGF-2 and SDF-1α, to wound sites, enhancing wound healing and tissue repair by providing a sustained release of growth factors over a period of time.

The original patent disclosed a composition for delivering multiple therapeutic proteins, but it had limitations in terms of stability, controlled release, and targeted delivery. The new inventive concept addresses these limitations by introducing a biodegradable linker for cross-linking the hydrogel, modifying the polycationic polymer with a targeting moiety, and designing the composition for controlled release over a period of time.

The new inventive concept comprises a hydrogel and a complex or coacervate of a polycationic polymer, a polyanionic polymer, FGF-2, and SDF-1α embedded in the hydrogel. The hydrogel is cross-linked with a biodegradable linker to enhance the stability of the complex or coacervate. The polycationic polymer is modified with a targeting moiety to enhance the delivery of the growth factors to the wound site. The composition is designed to release the growth factors in a controlled manner over a period of time, providing a sustained release of the growth factors to the wound site. This improves wound healing and tissue repair by promoting a more efficient and effective delivery of therapeutic proteins.

The new inventive concept introduces a biodegradable linker for cross-linking the hydrogel, modifies the polycationic polymer with a targeting moiety, and designs the composition for controlled release over a period of time. These features are not present in the original patent and provide a novel and non-obvious solution to the limitations of the original patent.

Alternative embodiments of the inventive concept could include using different types of biodegradable linkers, modifying the polycationic polymer with different targeting moieties, or using different ratios of polycationic to polyanionic polymers. Additionally, the composition could be designed to release the growth factors in response to specific stimuli, such as pH or temperature changes.

The new inventive concept has potential commercial applications in the wound healing and tissue repair industries, including treatment of chronic wounds, burns, and surgical wounds. The market for wound healing products is expected to grow significantly in the coming years, and the new inventive concept has the potential to capture a significant share of this market.