Hydrogel-based Delivery Systems for Environmental and Agricultural Applications

Publication ID: 24-11857631_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Hydrogel-based Delivery Systems for Environmental and Agricultural Applications,” Published Technical Disclosure No. 24-11857631_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857631_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,631.

Summary of the Inventive Concept

This inventive concept leverages the core technology of the original patent to develop novel hydrogel-based delivery systems for various environmental and agricultural applications, including crop yield improvement, soil pollution treatment, bioremediation of contaminated water, enhanced oil recovery, and industrial wastewater treatment.

Background and Problem Solved

The original patent focused on wound healing and tissue repair by delivering therapeutic proteins using a hydrogel-based system. However, this technology has broader potential applications in environmental and agricultural fields, where controlled release of proteins and enzymes can have significant benefits. The new inventive concept addresses the limitations of the original patent by adapting the hydrogel-based delivery system for these new applications, providing a more efficient and effective way to tackle environmental and agricultural challenges.

Detailed Description of the Inventive Concept

The new inventive concept involves the development of hydrogel-based delivery systems for environmental and agricultural applications. These systems comprise a complex or coacervate of a polycationic polymer, a polyanionic polymer, and a protein or enzyme tailored to the specific application. For example, in crop yield improvement, the delivery system can release plant growth-promoting proteins to enhance plant growth and productivity. In soil pollution treatment, the system can release pollutant-degrading enzymes to break down pollutants. Similarly, in bioremediation of contaminated water, the system can provide a nutrient source for microorganisms to degrade pollutants. In enhanced oil recovery, the system can release surfactants to improve oil extraction efficiency. Finally, in industrial wastewater treatment, the system can release enzymes to degrade organic pollutants. The hydrogel-based delivery system provides a controlled release of these proteins and enzymes, ensuring a sustained and effective treatment.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious compared to the original patent because it applies the core technology to entirely new fields and applications, requiring significant adaptations and innovations. The inventive step lies in the development of new complexes or coacervates of polycationic and polyanionic polymers with proteins or enzymes tailored to environmental and agricultural applications, and the integration of these complexes into hydrogel-based delivery systems.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different types of polymers, proteins, or enzymes, or variations in the hydrogel composition and structure. Additionally, the delivery system could be adapted for use in other environmental or agricultural applications, such as bioremediation of contaminated soil or air pollution treatment.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various environmental and agricultural industries, including crop yield improvement, soil pollution treatment, bioremediation of contaminated water, enhanced oil recovery, and industrial wastewater treatment. The market for these applications is substantial, with growing demand for sustainable and efficient solutions to environmental and agricultural challenges.

CPC Classifications

SectionClassGroup
A A61 A61K47/36
A A61 A61K9/0019
A A61 A61K9/06
A A61 A61K35/16
A A61 A61K35/19
A A61 A61K38/177
A A61 A61K38/18
A A61 A61K38/1825
A A61 A61K38/195
A A61 A61K47/34
A A61 A61K47/42
A A61 A61L15/225
A A61 A61L15/40
A A61 A61L15/44
A A61 A61L27/18
A A61 A61L27/20
A A61 A61L27/225
A A61 A61L27/26
A A61 A61L27/3616
A A61 A61L27/52
A A61 A61L27/54
A A61 A61L27/56
A A61 A61L31/041
A A61 A61L31/042
A A61 A61L31/046
A A61 A61L31/145
A A61 A61L31/16
A A61 A61P9/10
A A61 A61L2300/25
A A61 A61L2300/252
A A61 A61L2300/414
A A61 A61L2300/418
A A61 A61L2400/04
A A61 A61L2430/20

Field of Art

Biomaterials, polymer chemistry, and controlled drug/protein delivery systems, with expertise in hydrogel formulations, polymer complexation, and protein encapsulation techniques

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degrees in materials science, chemical engineering, or bioengineering, possessing knowledge of polymer synthesis, protein interactions, and delivery system design

Obviousness Rationale

A PHOSITA would recognize that the core technology of polymer-protein complexation within hydrogel matrices can be readily extended to diverse application domains by selecting appropriate proteins or enzymes. The fundamental mechanism of creating complex or coacervate systems with polycationic and polyanionic polymers remains consistent across different technical contexts. The adaptability of the hydrogel delivery system demonstrates predictable variations that would be obvious to a skilled practitioner familiar with controlled release technologies.

Obvious Combinations & Variations

Source Patent Element
Hydrogel composition with polycationic polymer, polyanionic polymer, and protein complex (FGF-2, SDF-1α)
PTD Variation
Replacing therapeutic proteins with environmental enzymes or agricultural growth-promoting proteins
Obviousness Reasoning
Known technique of protein substitution within established polymer complex framework, predictable results in controlled protein delivery
Source Patent Element
Specific polycationic polymer with copolymer backbone and pendant arginine groups
PTD Variation
Modifying polymer composition to optimize interactions with environmental enzymes or agricultural proteins
Obviousness Reasoning
Routine polymer engineering to adapt molecular structure for specific protein binding and release characteristics
Source Patent Element
Complex formation using heparin or heparan sulfate as polyanionic polymer
PTD Variation
Exploring alternative polyanionic polymers optimized for environmental and agricultural applications
Obviousness Reasoning
Finite set of known polyanionic polymers with predictable complexation behaviors, design choice based on specific application requirements
Source Patent Element
Controlled protein release within hydrogel matrix
PTD Variation
Extending controlled release mechanism to environmental enzyme delivery and agricultural protein systems
Obviousness Reasoning
Established technological principle of sustained protein/enzyme release applicable across multiple domains
Source Patent Element
Specific peptide sequences for polymer functionalization (IKVAV, RGD, RGDS)
PTD Variation
Developing novel peptide sequences to enhance protein binding or environmental system performance
Obviousness Reasoning
Known strategy of peptide engineering to modify polymer interactions, predictable molecular design approach
35 U.S.C. § 103 Summary: Based on US Patent 11857631's teachings of hydrogel-based protein delivery systems, the present publication demonstrates that a person having ordinary skill in the art would find the disclosed environmental and agricultural applications obvious through routine variations in protein selection, polymer composition, and delivery mechanism. The fundamental technological approach of creating polymer-protein complexes within a hydrogel matrix represents a predictable extension of the source patent's core technological principles.

Original Patent Information

Patent NumberUS 11,857,631
TitleProtection and delivery of multiple therapeutic proteins
Assignee(s)UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION