Synergistic Wound Healing System

Publication ID: 24-11857631_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Wound Healing System,” Published Technical Disclosure No. 24-11857631_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857631_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,631.

Summary of the Inventive Concept

A novel, integrated system for wound healing that combines a hydrogel composition with distinct technologies such as AI, IoT, blockchain, and novel biomaterials to provide personalized, real-time treatment and monitoring.

Background and Problem Solved

Current wound healing treatments are limited by the short half-lives and high costs of therapeutic proteins. The original patent addressed this issue by developing a hydrogel composition that protects and delivers multiple therapeutic proteins. However, this invention has limitations in terms of real-time monitoring and personalized treatment. The new inventive concept integrates the original hydrogel composition with AI, IoT, blockchain, and novel biomaterials to overcome these limitations.

Detailed Description of the Inventive Concept

The synergistic wound healing system consists of a hydrogel composition embedded with a complex or coacervate of a polycationic polymer, a polyanionic polymer, and a therapeutic protein. This composition is integrated with an AI-powered monitoring device that tracks wound healing progress and adjusts protein release accordingly. The system also includes an IoT-enabled sensor to monitor protein release and adjust the composition in real-time. Additionally, the system is integrated with a blockchain-based data management platform that securely tracks patient data and treatment outcomes. The composition may further comprise novel biomaterials such as graphene oxide, nanocellulose, and polyhydroxyalkanoates. The system may also utilize machine learning algorithms to analyze a patient's genetic profile and wound characteristics, generating a customized hydrogel composition tailored to the patient's specific needs.

Novelty and Inventive Step

The new claims introduce the integration of AI, IoT, blockchain, and novel biomaterials with the original hydrogel composition, providing a synergistic system that offers real-time monitoring, personalized treatment, and secure data management. This integration is non-obvious and novel compared to the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include different AI algorithms, IoT sensor configurations, blockchain platforms, and biomaterials. Variations of the system may also be developed for specific wound types, such as diabetic foot ulcers or burn wounds.

Potential Commercial Applications and Market

The synergistic wound healing system has significant commercial potential in the wound care industry, which is projected to reach $22.8 billion by 2025. The system's ability to provide personalized, real-time treatment and monitoring will appeal to hospitals, clinics, and patients seeking advanced wound care solutions.

CPC Classifications

SectionClassGroup
A A61 A61K47/36
A A61 A61K9/0019
A A61 A61K9/06
A A61 A61K35/16
A A61 A61K35/19
A A61 A61K38/177
A A61 A61K38/18
A A61 A61K38/1825
A A61 A61K38/195
A A61 A61K47/34
A A61 A61K47/42
A A61 A61L15/225
A A61 A61L15/40
A A61 A61L15/44
A A61 A61L27/18
A A61 A61L27/20
A A61 A61L27/225
A A61 A61L27/26
A A61 A61L27/3616
A A61 A61L27/52
A A61 A61L27/54
A A61 A61L27/56
A A61 A61L31/041
A A61 A61L31/042
A A61 A61L31/046
A A61 A61L31/145
A A61 A61L31/16
A A61 A61P9/10
A A61 A61L2300/25
A A61 A61L2300/252
A A61 A61L2300/414
A A61 A61L2300/418
A A61 A61L2400/04
A A61 A61L2430/20

Original Patent Information

Patent NumberUS 11,857,631
TitleProtection and delivery of multiple therapeutic proteins
Assignee(s)UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION