Protection and Delivery of Multiple Therapeutic Proteins for Specialized Wound Healing

An innovative system for delivering multiple therapeutic proteins to wounds in specific, challenging environments, enhancing wound healing outcomes in extreme cold, high-altitude, disaster relief, and compromised immune system scenarios.

The original patent disclosed a composition for delivering multiple therapeutic proteins for wound healing. However, this composition may not be suitable for use in extreme or specialized environments. The present inventive concept addresses this limitation by adapting the original composition for use in these specific scenarios, ensuring effective wound healing in challenging conditions.

The new inventive concept comprises a hydrogel and a complex or coacervate of a polycationic polymer, a polyanionic polymer, fibroblast growth factor 2 (FGF-2), and stromal cell-derived factor 1 alpha (SDF-1α) embedded in the hydrogel. The polycationic polymer is specifically designed to remain stable in extreme temperatures (below 0°C or above 37°C) or to be biodegradable within a certain timeframe (7-10 days). The polyanionic polymer is heparin or heparan sulfate. The system is designed for use in wound healing in extreme cold environments, high-altitude environments, disaster relief situations, and for treating chronic wounds in patients with diabetes or compromised immune systems.

The new claims introduce novel and non-obvious adaptations of the original composition for use in specialized environments, including the use of thermoresponsive polymers, biodegradable polymers, and specific polyanionic polymers. These adaptations provide a significant advantage in wound healing outcomes in these challenging scenarios.

Alternative embodiments of the inventive concept could include the use of different polycationic or polyanionic polymers, varying the concentration of the therapeutic proteins, or incorporating additional components to enhance wound healing. Variations could also include adapting the system for use in other specialized environments, such as high-humidity or high-radiation settings.

The inventive concept has significant commercial potential in the wound care market, particularly in niches such as extreme environment wound care, disaster relief, and chronic wound treatment. The system could be marketed to hospitals, clinics, and emergency response organizations, offering a unique solution for wound healing in challenging scenarios.