Synergistic Phosphorothioate-conjugated miRNA Systems

Publication ID: 24-11857633_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Phosphorothioate-conjugated miRNA Systems,” Published Technical Disclosure No. 24-11857633_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857633_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,633.

Summary of the Inventive Concept

This inventive concept integrates phosphorothioate-conjugated miRNAs with AI, IoT, blockchain, and other technologies to create powerful systems for treating diseases, personalized medicine, and non-invasive diagnostics.

Background and Problem Solved

The original patent disclosed phosphorothioate-conjugated miRNAs for treating multiple myeloma and inhibiting IL-6 signaling. However, these methods have limitations in terms of treatment outcomes, patient profiling, and data security. The new inventive concept addresses these limitations by combining the patented miRNA technology with synergistic technologies to create more effective and efficient systems.

Detailed Description of the Inventive Concept

The inventive concept comprises a microRNA-based therapy module, an AI-driven patient profiling module, and a blockchain-secured data storage module. The microRNA-based therapy module utilizes phosphorothioate-conjugated miRNAs to treat diseases such as multiple myeloma. The AI-driven patient profiling module analyzes patient data to optimize treatment outcomes. The blockchain-secured data storage module ensures secure sharing of genomic data. Additionally, IoT-enabled sensors and machine learning algorithms are integrated to collect and analyze patient data, predict treatment efficacy, and monitor treatment outcomes.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious because it combines the patented miRNA technology with distinct technologies such as AI, IoT, and blockchain to create synergistic systems that are more powerful and effective than the original patent. The inventive concept's integration of these technologies provides a new and innovative solution to the problems of treatment outcomes, patient profiling, and data security.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include integrating the microRNA-based therapy module with other AI-driven systems, such as decision support systems or natural language processing systems. Variations could include using different types of conjugated miRNAs or incorporating additional technologies such as nanotechnology or gene editing.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the fields of personalized medicine, disease treatment, and non-invasive diagnostics. The market for these applications is expected to grow rapidly in the coming years, driven by the increasing demand for more effective and efficient healthcare solutions.

CPC Classifications

SectionClassGroup
A A61 A61K47/549
A A61 A61K47/548
A A61 A61K48/00
C C12 C12N15/113
C C12 C12N2310/141
C C12 C12N2320/30

Field of Art

Molecular biology, biotechnology, and personalized medicine, with specific expertise in microRNA therapeutics, genetic engineering, and advanced computational approaches to medical treatment

Person of Ordinary Skill (PHOSITA) Profile

A researcher or practitioner with advanced degrees in molecular biology, bioinformatics, or biomedical engineering, possessing expertise in miRNA technologies, computational analysis, and interdisciplinary medical technologies

Obviousness Rationale

A PHOSITA would recognize that integrating computational technologies with existing microRNA therapeutic approaches represents a natural progression of biomedical innovation. The combination of phosphorothioate-conjugated miRNAs with AI, IoT, and blockchain technologies follows predictable pathways of technological convergence in personalized medicine. The source patent's foundational miRNA technology provides a clear technical foundation for extending therapeutic approaches through advanced computational and data management systems.

Obvious Combinations & Variations

Source Patent Element
Phosphorothioate-conjugated miRNAs for treating multiple myeloma
PTD Variation
Integration of AI-driven patient profiling to optimize miRNA therapeutic outcomes
Obviousness Reasoning
Applying machine learning to personalize therapeutic approaches is a known technique in precision medicine, representing a predictable extension of existing treatment methodologies
Source Patent Element
microRNA delivery methods for cellular targeting
PTD Variation
IoT-enabled sensors for real-time monitoring of treatment efficacy and patient response
Obviousness Reasoning
Continuous monitoring of therapeutic interventions is a standard approach in medical technologies, representing an obvious technological enhancement
Source Patent Element
Nucleic acid conjugation techniques for improved cellular penetration
PTD Variation
Blockchain-secured data storage for genomic information and treatment tracking
Obviousness Reasoning
Secure data management is a predictable solution for handling sensitive medical and genetic information across technological domains
Source Patent Element
miRNA targeting for specific cellular signaling pathways
PTD Variation
Machine learning algorithms for predicting treatment efficacy based on genetic profiles
Obviousness Reasoning
Computational prediction of treatment outcomes is a well-established approach in personalized medicine research
Source Patent Element
Therapeutic methods using specific microRNA sequences
PTD Variation
Decentralized AI-driven analytics for genomic data interpretation
Obviousness Reasoning
Applying advanced computational techniques to genetic data analysis represents a logical and predictable technological progression
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857633 and the disclosed technological variations, a person having ordinary skill in the art would find the integration of microRNA therapeutic technologies with computational systems to be an obvious and predictable extension of existing medical technologies. The combination of phosphorothioate-conjugated miRNAs with AI, IoT, and blockchain technologies represents a straightforward application of known techniques to existing therapeutic approaches, rendering potential claims in this domain obvious and unpatentable.

Original Patent Information

Patent NumberUS 11,857,633
TitlePhosphorothioate-conjugated miRNAs and methods of using the same
Assignee(s)City of Hope