Phosphorothioate-Conjugated miRNAs for Diverse Industrial Applications

Expanding the core technology of phosphorothioate-conjugated miRNAs to address unmet needs in environmental monitoring, agriculture, diagnostics, personalized medicine, and skin health

The original patent focused on treating diseases, particularly multiple myeloma and IL-6 signaling. However, the technology's potential extends beyond disease treatment. The new inventive concept addresses the limitations of the original patent by exploring novel applications and use cases, unlocking the technology's broader industrial potential

The new inventive concept leverages phosphorothioate-conjugated miRNAs in various industries. For instance, in environmental monitoring, miRNA sensors can detect specific pollutants. In agriculture, phosphorothioate-conjugated miRNAs can regulate genes involved in plant growth and development, improving crop yields. In diagnostics, miRNA probes can bind to biomarkers of neurological disorders. In personalized medicine, computational platforms can identify optimal miRNA combinations for treating specific diseases. Finally, in skin health, topical administration of phosphorothioate-conjugated miRNAs can regulate genes involved in skin inflammation

The new claims introduce novel applications and use cases that were not originally considered, expanding the technology's scope beyond disease treatment. The inventive step lies in the recognition of the technology's potential in diverse industrial settings and the development of new, non-obvious applications

Other potential embodiments include using phosphorothioate-conjugated miRNAs in bioremediation, biotechnology, or cosmetics. Variations may involve different miRNA sequences, conjugation methods, or delivery mechanisms

The inventive concept has significant commercial potential in various industries, including environmental monitoring, agriculture, diagnostics, personalized medicine, and skin health. The market size for these industries is substantial, and the technology's adoption could lead to significant revenue growth and societal impact