Adaptive MicroRNA Delivery Systems for Specialized Environments
Legal Citation
Summary of the Inventive Concept
This inventive concept adapts phosphorothioate-conjugated miRNAs for specialized environments, such as disaster relief, high-security needs, and extreme weather conditions, enabling targeted delivery and improved efficacy in niche applications.
Background and Problem Solved
The original patent disclosed phosphorothioate-conjugated miRNAs for treating multiple myeloma and inhibiting IL-6 signaling. However, these miRNAs may not be suitable for extreme environments or specialized applications. This inventive concept addresses the limitations of the original patent by developing adaptable miRNA delivery systems for specific, high-need markets.
Detailed Description of the Inventive Concept
The inventive concept comprises a microRNA delivery platform adapted for extreme weather conditions, high-security data storage using phosphorothioate-conjugated miRNAs, a portable miRNA delivery unit for emergency response, a microRNA-based detection system for biodefense, and environmental remediation using phosphorothioate-conjugated miRNAs. These systems and methods leverage the original patent's miRNA conjugates to target specific applications, ensuring improved efficacy and stability in challenging environments.
Novelty and Inventive Step
The new claims introduce novel adaptations of the original patent's miRNA conjugates, including temperature and humidity resistance, secure encryption protocols, solar-powered portable units, and multi-pathogen detection capabilities. These specialized features and functionalities constitute the inventive step, distinguishing the new concept from the original patent.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include miRNA delivery systems for space exploration, agricultural applications, or veterinary medicine. Variations could involve different types of miRNA conjugates, alternative encryption protocols, or modified detection systems.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in various industries, including disaster relief, biodefense, environmental remediation, and high-security data storage. Target markets could include government agencies, emergency response organizations, and private companies operating in extreme environments.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K47/549 |
| A | A61 | A61K47/548 |
| A | A61 | A61K48/00 |
| C | C12 | C12N15/113 |
| C | C12 | C12N2310/141 |
| C | C12 | C12N2320/30 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Molecular Biology and Pharmaceutical Biotechnology, focusing on microRNA delivery systems, nucleic acid conjugation, and targeted therapeutic interventions
Person of Ordinary Skill (PHOSITA) Profile
A researcher with advanced degrees in molecular biology or biochemistry, experienced in nucleic acid manipulation, drug delivery technologies, and understanding of chemical conjugation techniques for therapeutic applications
Obviousness Rationale
A person having ordinary skill in the art would recognize that the source patent's phosphorothioate-conjugated miRNA technology provides a foundational platform for specialized adaptations. The PTD's variations represent predictable extensions of known miRNA delivery principles, applying the core conjugation technology to specific environmental and functional contexts. The technical modifications demonstrate routine engineering adaptations that would be apparent to a skilled practitioner seeking to optimize miRNA delivery in challenging conditions.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,633 |
|---|---|
| Title | Phosphorothioate-conjugated miRNAs and methods of using the same |
| Assignee(s) | City of Hope |