Polyethylene Glycol-Linker Conjugate for Diverse Applications

Publication ID: 24-11857635_0007_PTD

Published: October 28, 2025

Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Polyethylene Glycol-Linker Conjugate for Diverse Applications,” Published Technical Disclosure No. 24-11857635_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857635_0007_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,635.

Summary of the Inventive Concept

This inventive concept explores novel applications of polyethylene glycol-linker conjugates and derivatives beyond pharmaceuticals, leveraging their versatility to address pressing issues in agriculture, environmental monitoring, cosmetics, and industrial wastewater treatment.

Background and Problem Solved

The original patent focused on polyethylene glycol-linker conjugates for pharmaceutical applications. However, the conjugates' unique properties and adaptability suggest broader potential. This inventive concept tackles the limitations of existing solutions in various industries by introducing the polyethylene glycol-linker conjugate technology, providing innovative solutions to pressing problems.

Detailed Description of the Inventive Concept

The inventive concept encompasses a range of applications, including: 1) treating agricultural crops to increase resistance to pests and diseases, 2) improving water quality by removing pollutants, 3) enhancing skin moisturizing and anti-aging effects in cosmetics, 4) monitoring environmental pollutants through selective detection, and 5) treating industrial wastewater by removing heavy metals and other pollutants. The polyethylene glycol-linker conjugate's structure and properties enable these diverse applications, offering a versatile platform for addressing complex challenges.

Novelty and Inventive Step

The new claims introduce unprecedented applications of polyethylene glycol-linker conjugates, deviating significantly from the original pharmaceutical focus. The inventive step lies in recognizing the conjugates' adaptability and repurposing them to tackle distinct problems in various industries.

Alternative Embodiments and Variations

Alternative embodiments may involve modifying the linker compound, polyethylene glycol residue, or drug moiety to optimize performance in specific applications. Variations could include using different polyethylene glycol molecular weights, linker lengths, or functional groups to tailor the conjugate's properties for distinct uses.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential across multiple industries, including agriculture, environmental monitoring, cosmetics, and industrial wastewater treatment. The market demand for innovative solutions in these areas is substantial, and the polyethylene glycol-linker conjugate technology is poised to capture a significant share of these markets.

CPC Classifications

Section	Class	Group
A	A61	A61K47/60
A	A61	A61K31/704
A	A61	A61P35/00

Section 103 Obviousness Analysis (PHOSITA)

▼

Field of Art

Pharmaceutical and chemical engineering, specifically polymer conjugation technologies with a focus on polyethylene glycol (PEG) linker systems for drug delivery and functional materials

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with advanced degrees in chemical engineering, polymer science, or pharmaceutical chemistry, possessing expertise in molecular conjugation techniques, polymer modification, and interdisciplinary material design

Obviousness Rationale

A PHOSITA would recognize the inherent versatility of PEG-linker conjugates based on the source patent's broad structural teachings, understanding that the fundamental molecular architecture enables adaptation across multiple technological domains. The modular nature of the conjugate system, with its interchangeable components (PEG, linker, functional group), suggests predictable variations in application that would be apparent to a skilled practitioner. The PTD's proposed extensions represent logical extrapolations of the source patent's core technological principles, utilizing known polymer conjugation strategies to address diverse technical challenges.

Obvious Combinations & Variations

Source Patent Element

Polyethylene glycol-linker-drug conjugate with modifiable structural components

PTD Variation

Agricultural crop treatment using PEG-linker conjugate for pest resistance

Obviousness Reasoning

Known polymer functionalization techniques enable predictable modification of conjugate properties for targeted interactions, representing a straightforward design choice within polymer engineering principles

Source Patent Element

Selective binding capabilities demonstrated in pharmaceutical drug conjugation

PTD Variation

Environmental pollutant detection and removal using PEG-linker system

Obviousness Reasoning

Selective molecular binding is a well-established technique in polymer chemistry, with the PEG-linker structure providing a versatile platform for adapting binding specificity to different target molecules

Source Patent Element

Diverse drug molecule integration into PEG-linker conjugate

PTD Variation

Cosmetic formulation enhancing skin moisturizing through molecular engineering

Obviousness Reasoning

Molecular design principles allow predictable property modifications, with PEG's known hydrophilic characteristics making skin interaction applications a logical extension

Source Patent Element

Structural flexibility in linker compound configuration

PTD Variation

Industrial wastewater treatment using selective heavy metal removal

Obviousness Reasoning

Polymer conjugation techniques provide established methods for creating molecules with specific binding and sequestration capabilities, representing a standard engineering approach to functional material design

35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857635, a person having ordinary skill in the art would find the variations disclosed in the Published Technical Disclosure to be obvious extensions of known polyethylene glycol-linker conjugate technologies. The structural modularity and predictable molecular interactions inherent in the source patent provide sufficient conceptual foundation to render the proposed applications prima facie obvious, thus anticipating potential patent claims through established polymer engineering principles.

Original Patent Information

Patent Number	US 11,857,635
Title	Linker compound, polyethylene glycol-linker conjugate and derivative thereof and polyethylene glycol-linker-drug conjugate
Assignee(s)	JenKem Technology Co., Ltd. (Tianjin)