AI-Integrated Polyethylene Glycol-Linker-Drug Conjugate System for Personalized Medicine

Publication ID: 24-11857635_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “AI-Integrated Polyethylene Glycol-Linker-Drug Conjugate System for Personalized Medicine,” Published Technical Disclosure No. 24-11857635_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857635_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,635.

Summary of the Inventive Concept

The present inventive concept integrates polyethylene glycol-linker-drug conjugates with advanced technologies such as artificial intelligence, Internet of Things, blockchain, and nanomaterials to create a powerful system for personalized medicine, enhancing treatment efficacy and patient outcomes.

Background and Problem Solved

The original patent disclosed polyethylene glycol-linker-drug conjugates with improved solubility and stability. However, these conjugates have limitations in terms of dosage optimization, patient response monitoring, and supply chain integrity. The present inventive concept addresses these limitations by integrating the conjugates with AI, IoT, blockchain, and nanomaterials, enabling real-time monitoring, data-driven decision making, and targeted drug delivery.

Detailed Description of the Inventive Concept

The system comprises a polyethylene glycol-linker-drug conjugate integrated with an artificial intelligence module for optimizing dosage and treatment schedules based on patient data and medical history. The system also includes IoT sensors for monitoring patient response and adjusting treatment accordingly. Additionally, the system incorporates a blockchain-based tracking system to ensure authenticity and supply chain integrity of the conjugates. Furthermore, the system can utilize nanomaterial-based delivery systems for targeted release and improved bioavailability. The inventive concept enables personalized medicine by combining genomics analysis, machine learning algorithms, and the polyethylene glycol-linker-drug conjugate to predict treatment efficacy and optimize therapy.

Novelty and Inventive Step

The present inventive concept introduces the novel integration of polyethylene glycol-linker-drug conjugates with AI, IoT, blockchain, and nanomaterials, which is not obvious from the original patent. The inventive concept's synergistic combination of these technologies enables real-time monitoring, data-driven decision making, and targeted drug delivery, providing a significant improvement over the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include integrating the polyethylene glycol-linker-drug conjugate with other advanced technologies such as robotics, 3D printing, or quantum computing. Additionally, the system could be adapted for different disease indications or patient populations, further expanding its commercial potential.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the pharmaceutical and biotechnology industries, particularly in the areas of personalized medicine, cancer treatment, and rare disease management. The system's ability to optimize treatment outcomes, reduce healthcare costs, and improve patient quality of life makes it an attractive solution for healthcare providers, pharmaceutical companies, and patients.

CPC Classifications

SectionClassGroup
A A61 A61K47/60
A A61 A61K31/704
A A61 A61P35/00

Original Patent Information

Patent NumberUS 11,857,635
TitleLinker compound, polyethylene glycol-linker conjugate and derivative thereof and polyethylene glycol-linker-drug conjugate
Assignee(s)JenKem Technology Co., Ltd. (Tianjin)