Intelligent Bio-Orthogonal Drug Activation Systems

Publication ID: 24-11857636_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Intelligent Bio-Orthogonal Drug Activation Systems,” Published Technical Disclosure No. 24-11857636_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857636_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,636.

Summary of the Inventive Concept

A novel approach to bio-orthogonal drug activation by integrating AI, IoT, blockchain, and nanomaterials to create personalized, targeted, and efficient treatment systems.

Background and Problem Solved

The original patent on bio-orthogonal drug activation using retro Diels-Alder reactions has limitations in terms of targeted delivery, real-time monitoring, and secure data management. The new inventive concept addresses these limitations by incorporating AI-powered diagnostic modules, IoT-enabled wearable devices, blockchain-based patient data management systems, and nanomaterial-based prodrug delivery systems.

Detailed Description of the Inventive Concept

The new inventive concept comprises a bio-orthogonal drug activation module, an AI-powered diagnostic module, and a blockchain-based patient data management system. The bio-orthogonal drug activation module uses a retro Diels-Alder reaction to activate a prodrug. The AI-powered diagnostic module analyzes patient data stored in the blockchain-based patient data management system to optimize prodrug activation. The system can be integrated with IoT-enabled wearable devices for real-time monitoring and machine learning-based predictive analytics for optimal treatment outcomes.

Novelty and Inventive Step

The new claims introduce the innovative combination of AI, IoT, blockchain, and nanomaterials with bio-orthogonal drug activation, enabling personalized, targeted, and efficient treatment systems. This integration is not obvious from the original patent and provides a significant advancement in the field.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different AI algorithms, various IoT devices, or alternative blockchain platforms. The inventive concept can also be adapted for different types of prodrugs, diseases, or treatment modalities.

Potential Commercial Applications and Market

The intelligent bio-orthogonal drug activation systems have vast commercial potential in the pharmaceutical, biotechnology, and healthcare industries. The market for targeted and personalized medicine is growing rapidly, and this inventive concept is poised to revolutionize the field with its innovative approach to bio-orthogonal drug activation.

CPC Classifications

SectionClassGroup
A A61 A61K47/6803
A A61 A61K31/435
A A61 A61K31/444
A A61 A61K31/704
A A61 A61K38/05
A A61 A61K39/3955
A A61 A61K39/39558
A A61 A61K47/22
A A61 A61K47/545
A A61 A61K47/555
A A61 A61K47/558
A A61 A61K47/6897
B B82 B82Y5/00
C C07 C07C33/16
C C07 C07D237/26
C C07 C07D257/08
Y Y02 Y02A50/30

Original Patent Information

Patent NumberUS 11,857,636
TitleBio-orthogonal drug activation
Assignee(s)Tagworks Pharmaceuticals B.V.