Published Technical Disclosure Archive

Quinone-Containing Conjugates for Diverse Applications

Publication ID: 24-11857638_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Quinone-Containing Conjugates for Diverse Applications,” Published Technical Disclosure No. 24-11857638_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857638_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,638.

Summary of the Inventive Concept

The present inventive concept discloses the application of quinone-containing conjugates to novel fields beyond proliferative disorders, including agriculture, medical devices, wastewater treatment, environmental monitoring, and heavy metal remediation.

Background and Problem Solved

The original patent disclosed quinone-containing conjugates for the detection and treatment of proliferative disorders. However, the conjugates' potential extends beyond this scope. The present inventive concept addresses the limitation of the original patent by exploring new applications and use cases for these conjugates, thereby expanding their utility and impact.

Detailed Description of the Inventive Concept

The quinone-containing conjugates of the present inventive concept comprise a cell-binding moiety and a payload. In the new applications, the cell-binding moiety is designed to selectively bind to targets in the respective fields, such as plant-binding peptides in agriculture, anti-biofilm antibodies in medical devices, peptides that selectively bind to pollutants in wastewater treatment, and peptides that selectively bind to heavy metals in environmental remediation. The payload is chosen based on the specific application, including fungicides, bactericides, antimicrobial agents, enzymes, fluorescent labels, and chelating agents.

Novelty and Inventive Step

The present inventive concept's novelty lies in the unexpected application of quinone-containing conjugates to diverse fields beyond proliferative disorders. The inventive step resides in the recognition of the conjugates' potential in these new areas and the design of novel cell-binding moieties and payloads tailored to each application.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include the use of different quinone-containing conjugate structures, various cell-binding moieties, or alternative payloads. Variations may also involve the combination of quinone-containing conjugates with other technologies, such as nanoparticles or liposomes, to enhance their efficacy and delivery.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in various industries, including agriculture, medical devices, wastewater treatment, environmental monitoring, and heavy metal remediation. The market for these applications is substantial, with opportunities for partnerships, collaborations, and licensing agreements.

CPC Classifications

SectionClassGroup
A A61 A61K47/6889
A A61 A61K31/122
A A61 A61K47/6891
A A61 A61K49/0039
A A61 A61K49/0043
A A61 A61K49/0052
C C07 C07D417/12
C C07 C07K16/30
G G01 G01N33/582

Field of Art

Biomedical and Chemical Engineering, focusing on conjugate design, specifically antibody-drug conjugates (ADCs) and targeted molecular systems with applications in pharmaceuticals, biotechnology, and environmental remediation

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in chemistry, chemical engineering, or biotechnology, possessing expertise in molecular design, conjugate synthesis, targeting strategies, and interdisciplinary application of molecular technologies

Obviousness Rationale

A PHOSITA would recognize that the fundamental structural principles of quinone-containing conjugates disclosed in the source patent are readily adaptable to diverse application domains by systematically modifying the cell-binding moiety and payload while maintaining the core conjugate architecture. The modular nature of the conjugate design inherently suggests potential for broad technological translation across different fields. The PTD demonstrates predictable variations that a skilled practitioner would find obvious given the source patent's comprehensive structural teachings.

Obvious Combinations & Variations

Source Patent Element
Antibody-drug conjugate with cell-binding moiety and payload connected via specific linker structures
PTD Variation
Replacing tumor-targeting antibodies with plant-binding peptides for agricultural applications
Obviousness Reasoning
Known technique of substituting targeting moieties while preserving conjugate structural principles, representing a predictable design variation
Source Patent Element
Quinone-containing molecular structures with modifiable linker components
PTD Variation
Incorporating fluorescent labels or chelating agents as alternative payloads for environmental monitoring and remediation
Obviousness Reasoning
Finite set of known payload options within molecular design space, representing routine engineering adaptation
Source Patent Element
Conjugate design allowing selective targeting through specific binding moieties
PTD Variation
Developing anti-biofilm antibody conjugates for medical device applications
Obviousness Reasoning
Extending targeting strategy to adjacent medical technology domain using well-understood molecular engineering principles
Source Patent Element
Complex molecular conjugate with interchangeable structural components
PTD Variation
Integrating enzyme-based payloads for wastewater treatment applications
Obviousness Reasoning
Predictable application of conjugate technology to solve environmental challenges using known molecular design strategies
Source Patent Element
Linker chemistry allowing payload attachment with specific chemical transformations
PTD Variation
Developing heavy metal remediation conjugates with selective peptide binding and chelation mechanisms
Obviousness Reasoning
Routine extension of molecular targeting principles to environmental remediation using established conjugate design methodologies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857638, the present published technical disclosure demonstrates that the claimed quinone-containing conjugate variations would have been obvious to a person having ordinary skill in the art at the time of invention, as the disclosed applications represent predictable extensions of known molecular design principles through routine engineering modifications that would have been apparent to a skilled practitioner in the field.

Original Patent Information

Patent NumberUS 11,857,638
TitleQuinone-containing conjugates
Assignee(s)Promega Corporation